DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Htr1a

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_032334.2	Gene:	Htr1a / 15550	MGIID:	96273	Length:	421	Species:	Mus musculus

Alignment Length:	397	Identity:	112/397 - (28%)
Similarity:	170/397 - (42%)	Gaps:	85/397 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SDSPSSELNIPYTVFEVL----VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGAL 93
            :|:..|.:...|.|...|    :...:::||..|:.....||.|:...||.|.|||:.||:|..|
Mouse    24 NDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVL 88

  Fly    94 GIPFAILASMGLPRNLH--ACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTA 156
            .:|.|.|..:.....|.  .|...::|.|:.||.||..|.|:::||||||..|:.|......|.|
Mouse    89 VLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRA 153

  Fly   157 IFIISMCWVAGTIVGFLPLFGWHA--DVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYT 219
            ..:||:.|:.|.::...|:.||..  |.::..||...:  |:.|.::..|.....|.||||..|.
Mouse   154 AALISLTWLIGFLISIPPMLGWRTPEDRSNPNECTISK--DHGYTIYSTFGAFYIPLLLMLVLYG 216

  Fly   220 HIYRVIIKQVRQIV----------------------TMN--PASDLSRRS--------------- 245
            .|:|....::|:.|                      ::|  |.|...|||
Mouse   217 RIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAV 281

  Fly   246 -------SAAVVQVTTPGRG-GH-----------------------TGTMLRVLGAARKRDVKAT 279
                   :..|::|...|.. ||                       |....|.:..||:|  |..
Mouse   282 RQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARER--KTV 344

  Fly   280 QNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCII--LSHLNSAVNPVLYAYHLKDFR 342
            :.|.||:..|::||:|.:.:..:..||......|:| |..||  |.:.||.:|||:|||..|||:
Mouse   345 KTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPEL-LGAIINWLGYSNSLLNPVIYAYFNKDFQ 408

  Fly   343 AALKNLL 349
            .|.|.::
Mouse   409 NAFKKII 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	58/171 (34%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	99/351 (28%)
Htr1a	NP_032334.2	7tm_4	48..>169	CDD:304433	43/120 (36%)
		7tm_1	53..400	CDD:278431	99/351 (28%)
		Agonist binding. /evidence=ECO:0000250	112..121		2/8 (25%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	133..135		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..268		6/30 (20%)
		Agonist binding. /evidence=ECO:0000250	358..362		2/3 (67%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	396..400		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910