DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and GPBAR1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001070659.1	Gene:	GPBAR1 / 151306	HGNCID:	19680	Length:	330	Species:	Homo sapiens

Alignment Length:	356	Identity:	80/356 - (22%)
Similarity:	134/356 - (37%)	Gaps:	89/356 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SPSSELNIPYTV------FEVLVAIVSIIGNVLVIIVFRRERKLRR-RTNYYIVSLAMADLLVGA 92
            :|:|...:|..:      ..:.:|.:.|..|:|:.:....:|:||. ....:.:||.:|.||.|
Human     2 TPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTG- 65

  Fly    93 LGIPFAILASMGLP-------RNLHACLF-----TVSLLVVLCTISIFCLVAVSVDRYWAILYPM 145
                   ||...||       |...:||.     ..|.|.:|..     |:.|..:||.|:|.|:
Human    66 -------LALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLAN-----LLLVHGERYMAVLRPL 118

  Fly   146 AYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNH---NQECLFVEVMDYNYLVFLYFATI 207
            ....::|     ..:.:.|....:...||..||    ||   ...|....:....|| :|....:
Human   119 QPPGSIR-----LALLLTWAGPLLFASLPALGW----NHWTPGANCSSQAIFPAPYL-YLEVYGL 173

  Fly   208 ITPALLMLAFYTHIYRVII---KQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLG 269
            :.||:...||.:  .||:.   :|::.|..:..|  :.|...:|:.:..|
Human   174 LLPAVGAAAFLS--VRVLATAHRQLQDICRLERA--VCRDEPSALARALT--------------- 219

  Fly   270 AARKRDVKATQNLSIIVLFFMICWIP-----LYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAV 329
               .|..:|...   .:|.|.:||.|     |.::...:...|   :.|...|..:.|...::|.
Human   220 ---WRQARAQAG---AMLLFGLCWGPYVATLLLSVLAYEQRPP---LGPGTLLSLLSLGSASAAA 275

  Fly   330 NPVLYAYHLKD------FRAALKNLLLKMMG 354
            .||  |..|.|      :|||.:..|..:.|
Human   276 VPV--AMGLGDQRYTAPWRAAAQRCLQGLWG 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/183 (25%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/299 (22%)
GPBAR1	NP_001070659.1	7tm_GPCRs	28..284	CDD:333717	70/308 (23%)
		TM helix 2	51..72	CDD:320095	8/28 (29%)
		TM helix 3	86..108	CDD:320095	6/26 (23%)
		TM helix 4	126..142	CDD:320095	1/15 (7%)
		TM helix 5	162..185	CDD:320095	7/23 (30%)
		TM helix 6	220..245	CDD:320095	7/27 (26%)
		TM helix 7	259..284	CDD:320095	8/26 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24246
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100