Protein Alignment AdoR and ADRA1B

DIOPT Version :9

• Sequence 1: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: XP_011532737.1
• Gene: ADRA1B / 147
• HGNCID: 278
• Length: 556
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 128/541 - (23%)
• Similarity: 218/541 - (40%)
• Gaps: 127/541 - (23%)

  Fly    13 SFEGPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIV--SIIGNVLVIIVFRRERKLRRR 75
            :|.||         ::.:.:|..|..::....:|..||.|.:  :|:||:|||:.....|.||..
Human    24 NFTGP---------NQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTP 79

  Fly    76 TNYYIVSLAMADLLVGALGIPF-AILASMG---LPRNLHACLFTVSLLVVLCTISIFCLVAVSVD 136
            |||:||:|||||||:....:|| |.|..:|   |.|..  |....::.|:.||.||..|.|:|:|
Human    80 TNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIF--CDIWAAVDVLCCTASILSLCAISID 142

  Fly   137 RYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADV-NHNQECLFVEVMDYNYLV 200
            ||..:.|.:.|...|..|.||..:...||..|::...||.||.... |.::||...|  :..|.:
Human   143 RYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTE--EPFYAL 205

  Fly   201 FLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQV-----------TT 254
            |....:...|..::|..|..:| ::.|:..:.:......::| .|....:::           :|
Human   206 FSSLGSFYIPLAVILVMYCRVY-IVAKRTTKNLEAGVMKEMS-NSKELTLRIHSKNFHEDTLSST 268

  Fly   255 PGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLY---------------------- 297
            ..:|.:..:.:.|......|:.||.:.|.|:|..|::||:|.:
Human   269 KAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLDPDSPPPTHLRVVPAPW 333

  Fly   298 ------------TINCIKAFCPDCYVHPKLTLFCII--LSHLNSAVNPVLYAYHLKDFRAALKNL 348
                        .::..::......:.|...:|.::  |.:.||.:||::|....|:|:.|
Human   334 GHSSIMNLPLVLPLDATRSGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRA---- 394

  Fly   349 LLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVG----EYSPIWLR----QQQEA 405
            .::::|                    .|......|..:.|..:|    .|.| |.|    ::.::
Human   395 FVRILG--------------------CQCRGRGRRRRRRRRRLGGCAYTYRP-WTRGGSLERSQS 438

  Fly   406 LKNSQLLPKCGVVSPCFNNINQTVAAVASVTTDLEREMWNIVEASSGAELGETSYEFPS-PAPGS 469
            .|:|  |...|   .|.:...:|:.:.:.....|.|          ||........||. .|||:
Human   439 RKDS--LDDSG---SCLSGSQRTLPSASPSPGYLGR----------GAPPPVELCAFPEWKAPGA 488

  Fly   470 QRSSERNSSSTVPPAPPAPAK 490
            ..|.         |||..|.:
Human   489 LLSL---------PAPEPPGR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	63/174 (36%)
		7tm_1	58..334	CDD:278431	85/327 (26%)
ADRA1B	XP_011532737.1	7tm_4	57..>181	CDD:304433	49/125 (39%)
		7tm_1	62..384	CDD:278431	85/327 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910