DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and Lgr5

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_034325.2	Gene:	Lgr5 / 14160	MGIID:	1341817	Length:	907	Species:	Mus musculus

Alignment Length:	538	Identity:	106/538 - (19%)
Similarity:	175/538 - (32%)	Gaps:	218/538 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ITDF--SFEGPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVL------------VAIVSIIGN 59
            :.||  .||..|..||:      .:.|.||.     |:...|.|            .|::::..|
Mouse   522 LEDFLLDFEEDLKALHS------VQCSPSPG-----PFKPCEHLFGSWLIRIGVWTTAVLALSCN 575

  Fly    60 VLV-IIVFRRERKLRRRTNYYIVS-------LAMADLLVGALGIPFAILASM------------- 103
            .|| :.||        ||..||.|       :|:.|:|   :|:..|:||::
Mouse   576 ALVALTVF--------RTPLYISSIKLLIGVIAVVDIL---MGVSSAVLAAVDAFTFGRFAQHGA 629

  Fly   104 ----GLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIF----II 160
                |:     .|.....|.:.....|||.|...:::|.:::    ..|.....:..:|    |:
Mouse   630 WWEDGI-----GCQIVGFLSIFASESSIFLLTLAALERGFSV----KCSSKFEVKAPLFSLRAIV 685

  Fly   161 SMCWVAGTIVGFLPLFGWHADVNHNQECL---FVEVMDYNYLVFLYFATIITPALLMLAFYTHIY 222
            .:|.:....:..:||.| .:..|.:..||   |.|.....|:|.|.....:. .|:|...||.:|
Mouse   686 LLCVLLALTIATIPLLG-GSKYNASPLCLPLPFGEPSTTGYMVALVLLNSLC-FLIMTIAYTKLY 748

  Fly   223 RVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVL 287
            ..:.|           .:|......::|:                               .|.:|
Mouse   749 CSLEK-----------GELENLWDCSMVK-------------------------------HIALL 771

  Fly   288 FFMICWIPLYTINCIKAFCPDC-----------YVHPKLTLF-CIILSHLNSAVNPVLYAYHLKD 340
            .|         .||| .:||..           ::.|.:..| .:::..|.|.:||:||.
Mouse   772 LF---------ANCI-LYCPVAFLSFSSLLNLTFISPDVIKFILLVIVPLPSCLNPLLYI----- 821

  Fly   341 FRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQQEA 405
                                        |.:.|..:.|.|          :|:::..|:|.:..:
Mouse   822 ----------------------------VFNPHFKEDMGS----------LGKHTRFWMRSKHAS 848

  Fly   406 LK--NSQLLPKCGVVSPCFNNINQTVAAV----ASVTTDLEREMWNIVEASSGAELGETSYEFPS 464
            |.  ||..:.|        .:...|.|.|    ||:..||        .::|||          |
Mouse   849 LLSINSDDVEK--------RSCESTQALVSFTHASIAYDL--------PSTSGA----------S 887

  Fly   465 PAPGSQRSSERNSSSTVP 482
            ||.....|...:|.:.||
Mouse   888 PAYPMTESCHLSSVAFVP 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	44/199 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	62/319 (19%)
Lgr5	NP_034325.2	LRRNT	33..70	CDD:214470
		leucine-rich repeat	68..91	CDD:275380
		LRR_RI	88..386	CDD:238064
		LRR_8	92..150	CDD:290566
		leucine-rich repeat	92..115	CDD:275380
		leucine-rich repeat	116..139	CDD:275380
		LRR_8	138..198	CDD:290566
		leucine-rich repeat	140..163	CDD:275380
		leucine-rich repeat	164..187	CDD:275380
		LRR_8	188..246	CDD:290566
		leucine-rich repeat	188..211	CDD:275380
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..258	CDD:275380
		LRR_8	257..314	CDD:290566
		leucine-rich repeat	259..282	CDD:275380
		leucine-rich repeat	283..304	CDD:275380
		LRR_8	352..410	CDD:290566
		leucine-rich repeat	354..375	CDD:275378
		leucine-rich repeat	376..389	CDD:275378
		leucine-rich repeat	400..423	CDD:275378
		leucine-rich repeat	445..467	CDD:275378
		7tm_1	575..820	CDD:278431	62/318 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910