DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AdoR and ADORA3

DIOPT Version :9

Sequence 1:NP_651772.1 Gene:AdoR / 43583 FlyBaseID:FBgn0039747 Length:774 Species:Drosophila melanogaster
Sequence 2:NP_000668.1 Gene:ADORA3 / 140 HGNCID:268 Length:318 Species:Homo sapiens


Alignment Length:320 Identity:105/320 - (32%)
Similarity:170/320 - (53%) Gaps:42/320 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 NIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGL 105
            |:.|...|:.:.:.:|:||||||.|.:....|:..|.|:|||||:||:.||.|.:|.||:.|:|:
Human    12 NVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGI 76

  Fly   106 PRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIV 170
            ..:.::|||...||::....||..|:|::||||..:...:.|.|....|.....:.:||:...:|
Human    77 TIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLV 141

  Fly   171 GFLPLFGWH----ADVNHN---QECLFVEVMDYNYLVFLYFAT-IITPALLMLAFYTHIYRVIIK 227
            |..|:|||:    ::.:.|   ..|.||.||..:|:|:..|.| |..|.::|.|.|..|:.:|  
Human   142 GLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYII-- 204

  Fly   228 QVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMIC 292
              |..:::|.::.                         :..||...|:.|..::|.:::..|.:.
Human   205 --RNKLSLNLSNS-------------------------KETGAFYGREFKTAKSLFLVLFLFALS 242

  Fly   293 WIPLYTINCIKAFCPDCYVHPKLTLFC-IILSHLNSAVNPVLYAYHLKDFRAALKNLLLK 351
            |:||..||||..|..:.   |:|.|:. |:|||.||.:||::|||.:|.|:.... |:||
Human   243 WLPLSIINCIIYFNGEV---PQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYL-LILK 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdoRNP_651772.1 7tm_4 52..>220 CDD:304433 65/175 (37%)
7tm_1 58..334 CDD:278431 93/284 (33%)
ADORA3NP_000668.1 7tm_GPCRs 13..293 CDD:333717 101/311 (32%)
TM helix 1 15..39 CDD:320095 10/23 (43%)
TM helix 2 48..70 CDD:320095 12/21 (57%)
TM helix 3 84..106 CDD:320095 8/21 (38%)
TM helix 4 129..145 CDD:320095 4/15 (27%)
TM helix 5 175..198 CDD:320095 8/22 (36%)
TM helix 6 226..251 CDD:320095 7/24 (29%)
TM helix 7 261..286 CDD:320095 13/24 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150901
Domainoid 1 1.000 181 1.000 Domainoid score I3483
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000536
OrthoInspector 1 1.000 - - otm40873
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24246
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.940

Return to query results.
Submit another query.