Protein Alignment AdoR and TAAR9

DIOPT Version :10

• Sequence 1: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_778227.3
• Gene: TAAR9 / 134860
• HGNCID: 20977
• Length: 348
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 90/350 - (25%)
• Similarity: 143/350 - (40%)
• Gaps: 92/350 - (26%)

  Fly    40 LNIPYT------VFEVL--VAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIP 96
            :..||:      ::.||  .|:::..||:||:|.....::|...||:.|.|||.||.|||...:|
Human    23 IKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMP 87

  Fly    97 FAILASM-------GLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTR 154
            |:.:.|:       ......|.|..|     ..|..|:|.|..:|||||.|:..|:.|.......
Human    88 FSTVRSVESCWYFGDSYCKFHTCFDT-----SFCFASLFHLCCISVDRYIAVTDPLTYPTKFTVS 147

  Fly   155 TAIFIISMCW------------------------VAGTIVGFLPLFGWHADVNHNQECLFVEVMD 195
            .:...|.:.|                        ||.|.||     |..|.:|.|
Human   148 VSGICIVLSWFFSVTYSFSIFYTGANEEGIEELVVALTCVG-----GCQAPLNQN---------- 197

  Fly   196 YNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGH 260
               .|.|.|.....|.:.|:..|:.|:.|...|.|:|  .:.||.....|.:...:|.
Human   198 ---WVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKI--ESTASQAQSSSESYKERVA------- 250

  Fly   261 TGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCI----KAFCPDCYVHPKLTLFCII 321
                        ||:.||.:.|.|.:..|::.|:| |.::.:    ..|....||: ::.::|:
Human   251 ------------KRERKAAKTLGIAMAAFLVSWLP-YLVDAVIDAYMNFITPPYVY-EILVWCV- 300

  Fly   322 LSHLNSAVNPVLYAYHLKDFRAALK 346
              :.|||:||::||:..:.|..|:|
Human   301 --YYNSAMNPLIYAFFYQWFGKAIK 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tmA_Adenosine_R	42..345	CDD:341316	88/345 (26%)
		TM helix 1	43..69	CDD:341316	10/33 (30%)
		TM helix 2	76..103	CDD:341316	13/26 (50%)
		TM helix 3	112..142	CDD:341316	12/29 (41%)
		TM helix 4	156..174	CDD:341316	7/41 (17%)
		TM helix 5	196..225	CDD:341316	7/28 (25%)
		TM helix 6	273..303	CDD:341316	10/33 (30%)
		TM helix 7	313..338	CDD:341316	8/24 (33%)
TAAR9	NP_778227.3	7tmA_TAAR6_8_9	33..322	CDD:320439	86/337 (26%)
		TM helix 1	34..60	CDD:320439	8/25 (32%)
		TM helix 2	67..93	CDD:320439	13/25 (52%)
		TM helix 3	105..135	CDD:320439	13/34 (38%)
		TM helix 4	147..170	CDD:320439	2/22 (9%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	174..187		3/12 (25%)
		TM helix 5	194..223	CDD:320439	9/41 (22%)
		TM helix 6	251..281	CDD:320439	10/30 (33%)
		TM helix 7	290..315	CDD:320439	10/28 (36%)