DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and GPRRK

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_317111.1	Gene:	GPRRK / 1277636	VectorBaseID:	AGAP008347	Length:	1257	Species:	Anopheles gambiae

Alignment Length:	685	Identity:	136/685 - (19%)
Similarity:	247/685 - (36%)	Gaps:	154/685 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DFSFEGPLLPLHAATTSKDAKDSDSPSSELNIP-YTVFE--------VLVAIVSIIGN--VLVII 64
            |..||..|...||:.|::.......|.....:| ..:|:        .:|.:::::||  |:.::
Mosquito   639 DEYFEDELGITHASPTAQPGSIQCLPEPGPFLPCQDLFDWWTLRCGVWVVFLLAMLGNGTVVFVL 703

  Fly    65 VFRRERKLRRRTNYYIVSLAMADLLVGA-LGIPFAILAS-------MGLPRNLHA-CLFTVSLLV 120
            :|.|.:....|  :.:.:||.||..:|. ||....:.||       ..:|..:.| |..:..|.|
Mosquito   704 IFSRSKMDVPR--FLVCNLAAADFFMGIYLGFLAVVDASTLGEFRMYAIPWQMSAGCKLSGFLAV 766

  Fly   121 VLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHN 185
            :...:|::.|..::::|.:||.:.|..::.:..|.|.:|:::.|.....:..|||.| .:|....
Mosquito   767 LSSELSVYTLAVITLERNYAITHAMHLNKRLSLRHASYIMTVGWTFAITMAVLPLLG-VSDYRVF 830

  Fly   186 QECLFVEVM----DYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSS 246
            ..||..|:.    ...|:|||.|...:. .|:::..|..:|..|
Mosquito   831 AVCLPFEIQKGTGSLAYVVFLMFINGVA-FLILMGCYLKMYCAI--------------------- 873

  Fly   247 AAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYV 311
                      ||..         |....|.:..:.::::|....|||.|:...:....|......
Mosquito   874 ----------RGSQ---------AWNSNDSRIAKRMALLVFTDFICWSPIAFFSLTAVFGLHLIS 919

  Fly   312 HPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAI----HRFSVASQ 372
            ..:..:|.:.:..|||..||.|||...|.|:   |:.:|....::..:....|    |..:.:::
Mosquito   920 LEQAKVFTVFILPLNSCCNPFLYAILTKQFK---KDCVLICKAIEESRVTRGIGRCRHSSNFSNR 981

  Fly   373 HRLQSMDSNM-RSTQ--PRLYVGEYSPIWLR-QQQEALKNSQLLPKCGVVSP-----CFNNINQT 428
            |...:.:|.: ||::  |.|..|:......: .:||:.:...:|...|....     ...|.:|.
Mosquito   982 HTPANTNSLVERSSKELPPLLPGQTCNCSAKLMEQESARLRLMLCSWGTADERNRRGRGRNGDQY 1046

  Fly   429 VAAVASVT----------------TDLEREMWNIVEASSGAEL-------GETSYEFP-SPAPGS 469
            ...:|.:.                :....:.|...:...|..|       ..||:... ..:..|
Mosquito  1047 AYQIAEIQQKQHKRAGSVSSSENFSSSRSDSWRNAQHHCGIPLRLLDPRRRHTSWLITRKTSQDS 1111

  Fly   470 QRSSERNSSSTVPPAPPAPAKPSVPSASYDNHNYSFSQDEDEDD---DDLEFEDVFVPASSVPNP 531
            ..||.||.||.             .:|:.....:..|:......   ..:..:.|..|.||....
Mosquito  1112 NLSSSRNDSSG-------------STATQSTGTWRISRSSGSTSVVLPGVRIDGVGHPVSSTARQ 1163

  Fly   532 VQPGIDPVELRRSLALVMREKLRSDDT---------------DSRPMGNNQDLPIDEQSRERPLS 581
            ..||..|..:|:|..        .:||               .:.|...:..:.:|:.:.|....
Mosquito  1164 SIPGGKPRLVRQSAV--------QEDTHELSCSPPRLGVRFLPTIPSAADSSVQLDDDTAEAASP 1220

  Fly   582 TQTSPTNGPLPALLRAKLLAGNSNSAHCLPGSTAS 616
            |.:...|.|.||...| :|.|:.      |.:|.|
Mosquito  1221 TSSQSGNQPAPAPFYA-ILHGSG------PQATVS 1248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	45/182 (25%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	63/290 (22%)
GPRRK	XP_317111.1	leucine-rich repeat	105..122	CDD:275380
		LRR_RI	<112..329	CDD:238064
		LRR_8	122..182	CDD:290566
		leucine-rich repeat	124..147	CDD:275380
		leucine-rich repeat	148..171	CDD:275380
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..219	CDD:275380
		LRR_8	220..278	CDD:290566
		leucine-rich repeat	220..243	CDD:275380
		leucine-rich repeat	244..267	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	268..291	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		LRR_8	315..368	CDD:290566
		leucine-rich repeat	315..336	CDD:275380
		LRR_RI	334..>520	CDD:238064
		leucine-rich repeat	337..358	CDD:275380
		leucine-rich repeat	361..429	CDD:275380
		LRR_8	382..440	CDD:290566
		leucine-rich repeat	408..422	CDD:275378
		LRR_8	430..488	CDD:290566
		leucine-rich repeat	430..453	CDD:275380
		leucine-rich repeat	454..477	CDD:275380
		LRR_8	477..530	CDD:290566
		leucine-rich repeat	478..501	CDD:275380
		leucine-rich repeat	502..523	CDD:275380
		7tm_4	689..>822	CDD:304433	32/134 (24%)
		7tm_1	695..942	CDD:278431	63/290 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910