DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and GPRMAC2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_003436890.1	Gene:	GPRMAC2 / 1274421	VectorBaseID:	AGAP004675	Length:	975	Species:	Anopheles gambiae

Alignment Length:	760	Identity:	165/760 - (21%)
Similarity:	287/760 - (37%)	Gaps:	235/760 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TVFEVLVAIVSII----GNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPF-AILASMG 104
            |:|..:...:.||    ||:||::.|..:|.:|:.:||:|.|||..|:|:|.:.:|| .:...||
Mosquito   124 TIFIAICLAICIILTIGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTVYVLMG 188

  Fly   105 LPRNLH--ACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRT-AIFIISMCWVA 166
            . .||.  .|...:|:...:|.:|.:.::.:::||:.::.....| |:.||:. .::::::.|:.
Mosquito   189 Y-WNLGPLLCDLWLSVDYTVCLVSQYTVLLITIDRFCSVKIAAKY-RSWRTKNKVLWMVTITWII 251

  Fly   167 GTIVGFLPLFGWHADVNHNQ----ECL--FVEVMDYN--YLVFLYFATIITPALLMLAFYTHIYR 223
            ..::.|:.:|||...|.:..    :|.  |::...:|  .::..|:.|::    ::...|..||:
Mosquito   252 PALLFFISIFGWEHFVGYRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLV----VLFVLYGGIYK 312

  Fly   224 VIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLF 288
            .       ...|...|:..:|...::|.:::    ..||...|..|..    :..||:..:
Mosquito   313 T-------AYDMQKKSEAKQRKMQSMVALSS----AMTGMASRTAGIG----ISKTQSTLL---- 358

  Fly   289 FMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMM 353
                             |.|    ..:|....::..|.:|.  ||.|
Mosquito   359 -----------------CTD----KPMTSSSPVVQKLEAAT--VLCA------------------ 382

  Fly   354 GVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQQEALKNSQLLPKCGVV 418
                  ..||..:|.:    ::||..| ::||...::                           |
Mosquito   383 ------GDEAFRKFDL----QIQSTTS-LQSTSINIH---------------------------V 409

  Fly   419 SPCFNNINQTVAAVASVTTDLEREMWNIVEASSGAELGE------TSYEFPSPAPGSQRSSERNS 477
            ||..|:.|.:.:....|.|. |:....|:.::....||:      |.||.......|:|||
Mosquito   410 SPSNNDKNFSKSLDPPVLTS-EKTNEGIIISNVSHALGDYRVEKATDYEERIEGEKSERSS---- 469

  Fly   478 SSTVPPAPPAPAKPSVPSASYDNHNYSFSQDEDEDDDDLEFEDVFVPASSVPNPVQPGIDPVELR 542
                     :||               |..||:...:..:.:.|               .|...|
Mosquito   470 ---------SPA---------------FDSDEEHSTNVKQVQYV---------------KPSHKR 495

  Fly   543 RSLALVMREK-----LRSDD-TDSRPMGNN-QDLPIDEQSRERPLSTQTSPTNGPLPALLRAKLL 600
            .|:|.::.|.     |.|:: |.|...||| ..|||      :.|||          ::...|.|
Mosquito   496 SSVAGMLVEAASASVLTSNNATSSISSGNNLSTLPI------KCLST----------SIFEQKAL 544

  Fly   601 A--GNSNSAHCLPGSTA-----SPAP-----QEQSGIFV---------IDSEASPGSNGHKPKYR 644
            :  ..:|..:|:..|.|     |.||     |.||...|         |..::|  |||.:..:
Mosquito   545 SSTNENNILNCITNSQAIDQELSFAPHSVISQTQSLAKVSCKTTCLQQILEDSS--SNGFQIAH- 606

  Fly   645 KGTAFTRSSLKKSRSCNCSSIAKGRGVHDEPSSNL------CRDQESSVLPQHPQPANHPTENFF 703
                .:...|::.|..:..||....|..| |..:|      ..|:.|.:||......|| ::|.|
Mosquito   607 ----VSHLKLREERPQSPISIEDTTGTSD-PLKSLDSADLRFMDESSIMLPTPENEINH-SDNSF 665

  Fly   704 SPLRSVGSFMQHSNLFHFLQPHAARPT---SSTASSTASTPTPSP 745
            :.|..|....::|..   ...:.|.||   .:...:||..|||||
Mosquito   666 TFLDDVAHLSKYSRC---SAQNIANPTLLHKALIQATAQCPTPSP 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/183 (25%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	62/287 (22%)
GPRMAC2	XP_003436890.1	7tm_1	141..>332	CDD:278431	49/203 (24%)
GPRMAC2	XP_003436890.1	7tm_4	142..>263	CDD:304433	34/122 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910