DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and GPRLKK

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_001230662.1	Gene:	GPRLKK / 1271106	VectorBaseID:	AGAP010851	Length:	561	Species:	Anopheles gambiae

Alignment Length:	556	Identity:	117/556 - (21%)
Similarity:	202/556 - (36%)	Gaps:	160/556 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPF----AILASMGL 105
            ::|...::|:::|||.|||.:....::::..||.:|.:||:||:.:|...|||    |:|....|
Mosquito    43 SLFYGTISILAVIGNSLVIWIVLTTKQMQTITNMFIANLALADVTIGVFAIPFQFQAALLQRWNL 107

  Fly   106 PRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRT----AIFIISMCWVA 166
            |..:  |.|...:.::...:|:|.|.|::|||:.||:.|:      |.||    :.|:||..|:.
Mosquito   108 PEFM--CPFCPFVQLISVNVSVFTLTAIAVDRHRAIINPL------RARTSKNISKFVISTIWML 164

  Fly   167 GTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVF-----LYFATIITPALLMLAFYTH----IY 222
            ...:....||.             :.|...:|:..     .|  |.||.....:..:.|    :|
Mosquito   165 SFALAAPILFA-------------LRVRPVSYIALGGMNETY--TNITVPFCKVVNFEHGEIQLY 214

  Fly   223 RVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTG--TMLRVLGAARKRDVKATQNLSII 285
            |.::..|:..|.:...|.:..:.:..:....|||....:.  |||       |...|..:.|.|:
Mosquito   215 RYVLVLVQYFVPLFVISFVYIQMALRLWGSKTPGNAQDSRDITML-------KNKKKVIKMLIIV 272

  Fly   286 VLFFMICWIPLYTINCIKAFCPDCYVHPKLTLF---CIILSHLNSAVNPVLYAYHLKDFRAALKN 347
            |..|.:||.||...|.:....|:...:..:.:.   |..|:..||..||.:|..:.:.|:...:
Mosquito   273 VALFGVCWFPLQLYNILHVTWPEINEYRFINIIWFVCDWLAMSNSCYNPFIYGIYNEKFKREFR- 336

  Fly   348 LLLKMMGVDIDQQAEAIHR-----------FSVASQHRLQSMDSNMRSTQ--------------- 386
               |......||.....|.           .||.|.:...|:.:.:.:.:
Mosquito   337 ---KRYPFKRDQTYNHNHESDKTSSIFTRVSSVRSTYATSSIRNKLSTNRYSGSKQLPAQFKFPP 398

  Fly   387 ----------------------PRLYVGE----------------YSPIWLRQQQEALKNSQLLP 413
                                  ||...||                ..|.|.::.:|..:|.
Mosquito   399 AGHHFPHHPVGGGHLHELSFGGPRKGAGEGLSVTSGTVTTNFGQNRPPSWEKRMEEPRQNE---- 459

  Fly   414 KCGVVSPCFNNINQTVAAVASVTTDLEREMWNIVEASSGAELGETSYEFPSPAPGS------QRS 472
                        ::.:...::.:.|.:.....:.|.|.|          ||...||      :..
Mosquito   460 ------------HEKLIVSSAASLDQQLASRQLTEDSVG----------PSDGFGSRIGAARRNG 502

  Fly   473 SERNSSSTVPPAPPAPAKPS--------VPSASYDN 500
            |.|.|:|||..|...|...|        .|:.::.|
Mosquito   503 SARESTSTVRMALNHPHPDSGGESGGDGEPNRAHSN 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	49/180 (27%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	77/297 (26%)
GPRLKK	XP_001230662.1	7tm_4	50..337	CDD:304433	81/320 (25%)
GPRLKK	XP_001230662.1	7tm_1	56..324	CDD:278431	77/297 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910