DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and GPRFSH

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_309589.2	Gene:	GPRFSH / 1270908	VectorBaseID:	AGAP004035	Length:	959	Species:	Anopheles gambiae

Alignment Length:	466	Identity:	100/466 - (21%)
Similarity:	173/466 - (37%)	Gaps:	138/466 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLHA--- 111
            :|.::::.|||.|::|....|.......:.|.:||.|||   .:|:...::||:    :.|:
Mosquito   577 VVVLLAVFGNVAVVVVLFSNRSDLTVPKFLICNLAFADL---CMGLYLLLIASI----DAHSMGE 634

  Fly   112 -------------CLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMC 163
                         |.....|.|....:|||.|..|:::|::||.:.:..:|.::...|::|:.:.
Mosquito   635 YFNYAFDWQYGVGCKVAGFLTVFASHLSIFTLTIVTLERWFAITHAIYLNRRIKLSAAMYIMIIG 699

  Fly   164 WVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPA--LLMLAFYTHIYRVII 226
            ||....:..:|||| .::.:....||.:|..|...:.:|....::...  ::::..|..||..:.
Mosquito   700 WVYAITMASMPLFG-ISNYSSTSICLPMEARDSLDIAYLLTVLVVNGCGFVVIVVCYAQIYLSLG 763

  Fly   227 KQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMI 291
            |:.||                       ..|..|:|.|.    .|:|        ::::|.....
Mosquito   764 KETRQ-----------------------AARSAHSGEMT----VAKK--------MALLVFTNFA 793

  Fly   292 CWIPL--YTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMG 354
            ||.|:  :.:..|..: |...| .|..:..:....|||..||.|||.....:|..|.:||.
Mosquito   794 CWAPIAFFGLTAIAGY-PLIGV-SKSKILLVFFYPLNSCANPYLYAILTVQYRKDLFSLLA---- 852

  Fly   355 VDIDQQAEAIHRFSVASQHRLQ-----SMDSNMRSTQPRLYVGEYSPIWLRQQQEALKNSQLLPK 414
                       .:.:.:|...|     ||.:|                          ..|:.|.
Mosquito   853 -----------NYGLCTQRAQQYKMTYSMPTN--------------------------TFQVAPA 880

  Fly   415 CGVVSPCFNNINQ-------TVAAVASVTTDLEREMWNIVEASS-----------GAELGETSYE 461
            .|.|:  :|:.|.       .:||:||..||   .:...|...|           |....:||..
Mosquito   881 RGSVN--YNSSNNGTITSAAGMAALASTNTD---TITTTVTCGSVVLNSNGNHGNGTATADTSAN 940

  Fly   462 FP----SPAPG 468
            .|    |..||
Mosquito   941 SPPNGTSAGPG 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	42/185 (23%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	66/295 (22%)
GPRFSH	XP_309589.2	leucine-rich repeat	154..181	CDD:275380
		leucine-rich repeat	204..229	CDD:275380
		leucine-rich repeat	246..274	CDD:275380
		leucine-rich repeat	275..299	CDD:275380
		LRR_8	279..335	CDD:290566
		leucine-rich repeat	300..324	CDD:275380
		leucine-rich repeat	325..345	CDD:275380
		leucine-rich repeat	346..368	CDD:275380
		7tm_1	585..836	CDD:278431	66/295 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910