DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and CNR2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001832.1	Gene:	CNR2 / 1269	HGNCID:	2160	Length:	360	Species:	Homo sapiens

Alignment Length:	375	Identity:	91/375 - (24%)
Similarity:	154/375 - (41%)	Gaps:	89/375 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ATTSKDAKDSDSPSSELNI-------PYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNY-YI 80
            |..|||..|| :|..:..|       ...|...|:.::|.:.||.|:.:.....:|||:.:| :|
Human    10 ANGSKDGLDS-NPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFI 73

  Fly    81 VSLAMADLLVGALGIPFAILASMGLPRNLH---------ACLFTVSLLVVLCTISIFCLVAVSVD 136
            .|||.||.|.   .:.||....     |.|         ..|..:..:.:..|.|:..|:..::|
Human    74 GSLAGADFLA---SVVFACSFV-----NFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAID 130

  Fly   137 RYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDY--NYL 199
            ||..:.||.:|...:....|:..:.:.||...:|.:|||.||........|...:...||  ::|
Human   131 RYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWL 195

  Fly   200 VFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTM 264
            :|:.|       |.....||:.: |:.|..:.:.:::                      ||...
Human   196 LFIAF-------LFSGIIYTYGH-VLWKAHQHVASLS----------------------GHQDR- 229

  Fly   265 LRVLGAARKR-DVKATQNLSIIVLFFMICWIPLYTI-----------NCIKAFCPDCYVHPKLTL 317
             :|.|.||.| ||:..:.|.:::...:|||.|:..:           ...|||.
Human   230 -QVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFA----------- 282

  Fly   318 FCIILSHLNSAVNPVLYAYHLKDFRAALKNLL------LKMMGVDIDQQA 361
            ||.:|..:||.||||:||....:.|::..:.|      ::.:|.:..::|
Human   283 FCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEA 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/179 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	74/299 (25%)
CNR2	NP_001832.1	7tmA_CB2	34..310	CDD:320463	80/326 (25%)
		TM helix 1	36..60	CDD:320463	6/23 (26%)
		TM helix 2	70..91	CDD:320463	10/23 (43%)
		TM helix 3	107..129	CDD:320463	4/21 (19%)
		TM helix 4	152..168	CDD:320463	3/15 (20%)
		TM helix 5	187..210	CDD:320463	8/29 (28%)
		TM helix 6	244..266	CDD:320463	5/21 (24%)
		TM helix 7	278..303	CDD:320463	14/35 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..360		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910