DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and GPR139

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001002911.1	Gene:	GPR139 / 124274	HGNCID:	19995	Length:	353	Species:	Homo sapiens

Alignment Length:	401	Identity:	82/401 - (20%)
Similarity:	155/401 - (38%)	Gaps:	113/401 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 HAATTSKDAKDSDSPSSELNIPY--TVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNY-YIVSL 83
            ||...:..:....||.|...:.:  .|:..|:..:.:..|:|.:|:..:....|::::| |:::|
Human     5 HAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLAL 69

  Fly    84 AMADLLVGALGIPFA------ILASMGLPR------------NLHACLFTVSLLVVLCTISIFCL 130
            |.||:|| ...|.|.      .:.:|.:|:            ::|.              ||:..
Human    70 AAADILV-LFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHT--------------SIWIT 119

  Fly   131 VAVSVDRYWAILYPMAY---SRNVRTRTAIFIISM-CWVAGTIVGFLPLFGWHADVNHNQECLFV 191
            |.:::|||.|:.:|:.|   |...|||..|..:.: |::..     :|.:.|......:    ::
Human   120 VPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTS-----IPYYWWPNIWTED----YI 175

  Fly   192 EVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPG 256
            ....::.|::::..|:.   |:..:.:..:..:|:.::|            |:|:..:
Human   176 STSVHHVLIWIHCFTVY---LVPCSIFFILNSIIVYKLR------------RKSNFRL------- 218

  Fly   257 RGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIP-----LYTINCIKAFCPDCYVHPKLT 316
            ||..||              |.|..|..|...|...|.|     ||.:          |..|...
Human   219 RGYSTG--------------KTTAILFTITSIFATLWAPRIIMILYHL----------YGAPIQN 259

  Fly   317 LFCI--------ILSHLNSAVNPVLYAYHLKDFR---AALKNLLLKMMGVDIDQQAEAIHRFSVA 370
            .:.:        :|:.||:|:|..||.:..|.||   ||......|.....:  |....|.||:.
Human   260 RWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPV--QFYTNHNFSIT 322

  Fly   371 SQHRLQSMDSN 381
            |...:...:|:
Human   323 SSPWISPANSH 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	37/190 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	61/311 (20%)
GPR139	NP_001002911.1	7tmA_GPR139	27..296	CDD:320585	68/338 (20%)
		TM helix 1	29..53	CDD:320585	5/23 (22%)
		TM helix 2	63..85	CDD:320585	10/22 (45%)
		TM helix 3	102..124	CDD:320585	4/35 (11%)
		TM helix 4	147..163	CDD:320585	2/20 (10%)
		TM helix 5	181..204	CDD:320585	3/25 (12%)
		TM helix 6	227..249	CDD:320585	6/21 (29%)
		TM helix 7	264..289	CDD:320585	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910