DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Adrb1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_031445.2	Gene:	Adrb1 / 11554	MGIID:	87937	Length:	466	Species:	Mus musculus

Alignment Length:	355	Identity:	100/355 - (28%)
Similarity:	160/355 - (45%)	Gaps:	60/355 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PSSELNIPYT--------VFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGA 92
            |:||.:.|.:        :...|:.::.::||||||:...:..:|:..||.:|:|||.|||::|.
Mouse    45 PASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGL 109

  Fly    93 LGIPF-AILASMGLPRNLHACLF-----TVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNV 151
            |.:|| |.:...|  |..:...|     :|.:|.|..:|...|::|  :|||.||..|..|...:
Mouse   110 LVVPFGATIVVWG--RWEYGSFFCELWTSVDVLCVTASIETLCVIA--LDRYLAITSPFRYQSLL 170

  Fly   152 RTRTAIFIISMCWVAGTIVGFLPLF--GWHADVNHNQECLFVEVMDYN------------YLVFL 202
            ....|..::...|....:|.|||:.  .|.|:.:..:.|       ||            |.:..
Mouse   171 TRARARALVCTVWAISALVSFLPILMHWWRAESDEARRC-------YNDPKCCDFVTNRAYAIAS 228

  Fly   203 YFATIITPALLMLAFYTHIYRVIIKQVRQIVTM------NPASDLSRRSSAAVVQVTTPGRGGHT 261
            ...:...|..:|...|..::|...|||::|.:.      .||...|...|      .:||.....
Mouse   229 SVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPEPS------PSPGPPRPA 287

  Fly   262 GTMLRVLGAARK-------RDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFC 319
            .::.....:.|:       |:.||.:.|.||:..|.:||:|.:..|.:|||..| .|..:|.:|.
Mouse   288 DSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRD-LVPDRLFVFF 351

  Fly   320 IILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            ..|.:.|||.||::|. ...|||.|.:.||
Mouse   352 NWLGYANSAFNPIIYC-RSPDFRKAFQRLL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	52/187 (28%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	88/308 (29%)
Adrb1	NP_031445.2	7tmA_Beta1_AR	59..376	CDD:320624	93/335 (28%)
		TM helix 1	60..86	CDD:320624	7/25 (28%)
		TM helix 2	93..120	CDD:320624	14/26 (54%)
		TM helix 3	131..161	CDD:320624	10/31 (32%)
		TM helix 4	175..193	CDD:320624	4/17 (24%)
		TM helix 5	221..253	CDD:320624	5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..302		7/43 (16%)
		TM helix 6	306..336	CDD:320624	11/29 (38%)
		TM helix 7	345..370	CDD:320624	9/25 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..466
		PDZ-Binding. /evidence=ECO:0000250	463..466
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910