DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and Adra1d

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_038488.4	Gene:	Adra1d / 11550	MGIID:	106673	Length:	562	Species:	Mus musculus

Alignment Length:	356	Identity:	99/356 - (27%)
Similarity:	161/356 - (45%)	Gaps:	39/356 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SKDAKDSDSPSSELN--------------IPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTN 77
            |..|:...:.|.|:|              :...||.....:.::.||:|||:.....|.|:..||
Mouse    62 SSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTN 126

  Fly    78 YYIVSLAMADLLVGALGIPFA----ILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRY 138
            |:||:||:||||:.|..:||:    :|......|..  |....::.|:.||.||..|..:|||||
Mouse   127 YFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTF--CDVWAAVDVLCCTASILSLCTISVDRY 189

  Fly   139 WAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQE-CLFVEVMDYNYLVFL 202
            ..:.:.:.|...:..|.|..|:::.|....:|...||.||...|..::. |...|  :..|.:|.
Mouse   190 VGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITE--EVGYAIFS 252

  Fly   203 YFATIITPALLMLAFYTHIYRVIIKQVRQI---VTMNP--ASDLSRR---SSAAVVQVTTPGRGG 259
            ...:...|..:::..|..:|.|.....|.:   :...|  ||::..|   ..||......||...
Mouse   253 SVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGNPGTQS 317

  Fly   260 HTGTMLRVLGAAR----KRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCI 320
            ..|..||...:.|    .|:.||.:.|:|:|..|::||.|.:.:..:.:..|.  :.|...:|.:
Mouse   318 SKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQ--LKPSEGVFKV 380

  Fly   321 I--LSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            |  |.:.||.|||::|....::|:.|...||
Mouse   381 IFWLGYFNSCVNPLIYPCSSREFKRAFLRLL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	52/172 (30%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	87/294 (30%)
Adra1d	NP_038488.4	7tm_GPCRs	91..407	CDD:333717	91/321 (28%)
		TM helix 1	93..117	CDD:320095	7/23 (30%)
		TM helix 2	126..148	CDD:320095	13/21 (62%)
		TM helix 3	164..186	CDD:320095	6/21 (29%)
		TM helix 4	209..225	CDD:320095	3/15 (20%)
		TM helix 5	246..269	CDD:320095	3/22 (14%)
		TM helix 6	338..363	CDD:320095	9/24 (38%)
		TM helix 7	375..400	CDD:320095	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910