Protein Alignment AdoR and Adora2b

DIOPT Version :9

• Sequence 1: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_031439.2
• Gene: Adora2b / 11541
• MGIID: 99403
• Length: 332
• Species: Mus musculus
• Alignment Length: 332
• Identity: 112/332 - (33%)
• Similarity: 167/332 - (50%)
• Gaps: 62/332 - (18%)

  Fly    44 YTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRN 108
            |...|:::|.:::.|||||.........|:..|||::||||.||:.||...|||||..|:|...:
Mouse    10 YVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLGFCTD 74

  Fly   109 LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFL 173
            .|.|||....::||...|||.|:||:||||.||..|:.|...|....|..||::.||....:|..
Mouse    75 FHGCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLT 139

  Fly   174 PLFGWHA------------DVNHNQE-----CLFVEVMDYNYLV-FLYFATIITPALLMLAFYTH 220
            |..||::            |...|:.     |||..|:..:|:| |.:|..::.|.|:||..|..
Mouse   140 PFLGWNSKDSATSNCTELGDGIANKSCCPVTCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIK 204

  Fly   221 IYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSII 285
            |:.|..||::::..|:                       |:.|.|       :|::.|.::|::|
Mouse   205 IFMVACKQLQRMELMD-----------------------HSRTTL-------QREIHAAKSLAMI 239

  Fly   286 VLFFMICWIPLYTINCIKAFCPDCYVHPKLTL--------FCIILSHLNSAVNPVLYAYHLKDFR 342
            |..|.:||:|::.||||..|      ||.|..        ..|:|||.||.|||::|||..:|||
Mouse   240 VGIFALCWLPVHAINCITLF------HPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFR 298

  Fly   343 AALKNLL 349
            .:...::
Mouse   299 YSFHKII 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	70/185 (38%)
		7tm_1	58..334	CDD:278431	103/301 (34%)
Adora2b	NP_031439.2	7tm_4	17..>134	CDD:304433	51/116 (44%)
		7tm_1	24..290	CDD:278431	103/301 (34%)
		Agonist binding. /evidence=ECO:0000250	173..182		2/8 (25%)
		Agonist binding. /evidence=ECO:0000250	247..254		2/6 (33%)
		Agonist binding. /evidence=ECO:0000250	266..276		0/9 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841012
Domainoid	1	1.000	175	1.000	Domainoid score	I3630
eggNOG	1	0.900	-	-		E33208_3BF5B
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000536
OrthoInspector	1	1.000	-	-		otm42945
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24246
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5322
SonicParanoid	1	1.000	-	-		X919
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830