DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdoR and Adora2a

DIOPT Version :9

Sequence 1:NP_651772.1 Gene:AdoR / 43583 FlyBaseID:FBgn0039747 Length:774 Species:Drosophila melanogaster
Sequence 2:NP_001318024.1 Gene:Adora2a / 11540 MGIID:99402 Length:410 Species:Mus musculus


Alignment Length:319 Identity:116/319 - (36%)
Similarity:173/319 - (54%) Gaps:39/319 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 YTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRN 108
            |.:.|:.:|:::|:|||||.........|:..||:::||||.||:.||.|.|||||..|.|....
Mouse     6 YIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAA 70

  Fly   109 LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFL 173
            .|.|||....::||...|||.|:|:::|||.||..|:.|:..|....|..||::|||....:|..
Mouse    71 CHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGMRAKGIIAICWVLSFAIGLT 135

  Fly   174 PLFGWH----ADVNHNQ-------ECLFVEVMDYNYLVFL-YFATIITPALLMLAFYTHIYRVII 226
            |:.||:    .|.|..:       .|||.:|:..||:|:. :||.::.|.|||||.|..|:....
Mouse   136 PMLGWNNCSQKDENSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAAR 200

  Fly   227 KQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMI 291
            :|::|:.:.                   |..|..|.:.|       :::|.|.::|:|||..|.:
Mouse   201 RQLKQMESQ-------------------PLPGERTRSTL-------QKEVHAAKSLAIIVGLFAL 239

  Fly   292 CWIPLYTINCIKAFCPDC-YVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            ||:||:.|||...||..| :..|.|....|||||.||.|||.:|||.:::||...:.::
Mouse   240 CWLPLHIINCFTFFCSTCQHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKII 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdoRNP_651772.1 7tm_4 52..>220 CDD:304433 73/179 (41%)
7tm_1 58..334 CDD:278431 107/288 (37%)
Adora2aNP_001318024.1 7tmA_Adenosine_R_A2A 4..294 CDD:320196 116/313 (37%)
TM helix 1 5..31 CDD:320196 9/24 (38%)
TM helix 2 38..65 CDD:320196 16/26 (62%)
TM helix 3 74..104 CDD:320196 14/29 (48%)
TM helix 4 118..136 CDD:320196 7/17 (41%)
Agonist binding. /evidence=ECO:0000250 163..172 3/8 (38%)
TM helix 5 169..199 CDD:320196 13/29 (45%)
TM helix 6 221..251 CDD:320196 14/29 (48%)
Agonist binding. /evidence=ECO:0000250 241..248 3/6 (50%)
Agonist binding. /evidence=ECO:0000250 259..269 2/9 (22%)
TM helix 7 262..287 CDD:320196 15/24 (63%)
Interaction with GAS2L2. /evidence=ECO:0000250|UniProtKB:P30543 322..410
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 342..410
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841011
Domainoid 1 1.000 175 1.000 Domainoid score I3630
eggNOG 1 0.900 - - E33208_3BF5B
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000536
OrthoInspector 1 1.000 - - otm42945
orthoMCL 1 0.900 - - OOG6_107098
Panther 1 1.100 - - LDO PTHR24246
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5322
SonicParanoid 1 1.000 - - X919
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.730

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