Protein Alignment AdoR and CHRM5

DIOPT Version :9

• Sequence 1: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001307846.1
• Gene: CHRM5 / 1133
• HGNCID: 1954
• Length: 532
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 106/514 - (20%)
• Similarity: 164/514 - (31%)
• Gaps: 194/514 - (37%)

  Fly    22 HAATTSKDAKDSDSPSSELNIPYTVFEVL--------VAIVSIIGNVLVIIVFRRERKLRRRTNY 78
            |.|||......:..|...    :.::||:        |::::|:|||||:|.|:...:|:...||
Human     7 HNATTVNGTPVNHQPLER----HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNY 67

  Fly    79 YIVSLAMADLLVGALGI----PFAILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYW 139
            |::|||.|||::|...:    .:.::....|  ...||...::|..|....|:..|:.:|.|||:
Human    68 YLLSLACADLIIGIFSMNLYTTYILMGRWAL--GSLACDLWLALDYVASNASVMNLLVISFDRYF 130

  Fly   140 AILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHN----QECLFVEVMDYNYLV 200
            :|..|:.|......:.|..:|.:.|:...|:....:..|...|...    .||....:.:.....
Human   131 SITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITF 195

  Fly   201 FLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTM------------------------------ 235
            ....|....|..:|...|..|||...|:.:.:..:
Human   196 GTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPT 260

  Fly   236 ------NPAS-DLSRRSSAA---------------------------------------VVQVTT 254
                  |.|| ..||||::.                                       |:||..
Human   261 LAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVY 325

  Fly   255 PGRGGH--------------------------TGTMLRVLGAA---------------------- 271
            ..:|..                          |...|....||
Human   326 KSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGN 390

  Fly   272 --------------------------------------RKRDV-----KATQNLSIIVLFFMICW 293
                                                  |||.|     ||.|.||.|:|.|:|.|
Human   391 QETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITW 455

  Fly   294 IPLYTINCIKAFCPDCYVHPKLTLFCI--ILSHLNSAVNPVLYAYHLKDFRAALKNLLL 350
            .|...:..:..||..|.   .:||:.:  .|.::||.|||:.||...:.||...|.|||
Human   456 TPYNIMVLVSTFCDKCV---PVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	45/175 (26%)
		7tm_1	58..334	CDD:278431	89/452 (20%)
CHRM5	NP_001307846.1	7tm_4	40..>167	CDD:304433	38/128 (30%)
		7tm_1	47..>225	CDD:278431	48/179 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..294		7/31 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910