DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and OPN1MW3

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001316996.1	Gene:	OPN1MW3 / 101060233	HGNCID:	51831	Length:	364	Species:	Homo sapiens

Alignment Length:	370	Identity:	86/370 - (23%)
Similarity:	147/370 - (39%)	Gaps:	100/370 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 TVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADL--------------LVG--AL 93
            :|:.:.|.|.|:..|.||:....:.:|||...|:.:|:||:|||              :.|  .|
Human    57 SVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVL 121

  Fly    94 GIPFAILASMGLPRNLHACLFTVSLLVVLCTIS-IFCLVAVSVDRYWAILYPMAYSRNVR--TRT 155
            |.|..:|..           :|||    ||.|: ::.|..:|.:|:..:..|..   |||  .:.
Human   122 GHPMCVLEG-----------YTVS----LCGITGLWSLAIISWERWMVVCKPFG---NVRFDAKL 168

  Fly   156 AIFIISMCWVAGTIVGFLPLFGW-----HA-------DVNHNQECLFVEVMDYNYLVFLYFATII 208
            ||..|:..|:...:....|:|||     |.       ||........|:    :|::.|.....|
Human   169 AIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQ----SYMIVLMVTCCI 229

  Fly   209 TPALLMLAFYTHIY---RVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGA 270
            ||..:::..|..::   |.:.||.::       |:                             :
Human   230 TPLSIIVLCYLQVWLAIRAVAKQQKE-------SE-----------------------------S 258

  Fly   271 ARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYA 335
            .:|.:.:.|:.:.::||.|..||.|.....|..|..|....||.:.......:...:..|||:|.
Human   259 TQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYV 323

  Fly   336 YHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDS 380
            :..:.||    |.:|::.|..:|..:|    .|.||:..:.|:.|
Human   324 FMNRQFR----NCILQLFGKKVDDGSE----LSSASKTEVSSVSS 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	51/198 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	69/309 (22%)
OPN1MW3	NP_001316996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	17..43
		7tm_4	61..>178	CDD:304433	37/134 (28%)
		7tm_1	71..322	CDD:278431	69/308 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910