DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and NPY4R2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001265724.1	Gene:	NPY4R2 / 100996758	HGNCID:	52383	Length:	375	Species:	Homo sapiens

Alignment Length:	425	Identity:	99/425 - (23%)
Similarity:	169/425 - (39%)	Gaps:	104/425 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLPLHAATTSKDAKDSDSPSSELNIPYTVFE-------VLV---------AIVSIIGNVLVIIVF 66
            |||        .:...::.|..|..||...|       |:|         .:|.::||:.::.|.
Human    10 LLP--------KSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVT 66

  Fly    67 RRERKLRRRTNYYIVSLAMADLLVGALGIP----FAILASMGLPRNLHACLFTVSLLVVLCTISI 127
            .|:::....||..|.:||.:|.|:..|..|    :.|:........|  |..:..:..:..|:||
Human    67 VRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETL--CKMSAFIQCMSVTVSI 129

  Fly   128 FCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFG-------WHADVNHN 185
            ..||.|:::|:..|:.|..:..::  ..|...|.:.||...::. ||...       :|.  ||:
Human   130 LSLVLVALERHQLIINPTGWKPSI--SQAYLGIVLIWVIACVLS-LPFLANSILENVFHK--NHS 189

  Fly   186 Q--ECLFVEVMDYNYLVFLYFATIITPALLM----------LAFYTHIYRVIIKQVRQIVTMNPA 238
            :  |.|..:|:........:..||.|..||:          |..|..|||.:.:|
Human   190 KALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQ---------- 244

  Fly   239 SDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIK 303
                             ||..|.||.  .|.|...:.|...  |.::|:.|.:.|:||:..|.::
Human   245 -----------------GRVFHKGTY--SLRAGHMKQVNVV--LVVMVVAFAVLWLPLHVFNSLE 288

  Fly   304 AF----CPDCYVHPKLT-LFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEA 363
            .:    .|.|  |..|. |.|.:|:..::.|||.:|.:...:|:..:|.|:|..      ||:..
Human   289 DWHHEAIPIC--HGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTC------QQSAP 345

  Fly   364 IHRFSVASQH-RLQSMDSNMRSTQPRLYVGEYSPI 397
            :..    |:| .|.::.:.:.....|| .|..:||
Human   346 LEE----SEHLPLSTVHTEVSKGSLRL-SGRSNPI 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	45/190 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	73/303 (24%)
NPY4R2	NP_001265724.1	7tmA_NPY4R	42..333	CDD:320519	77/330 (23%)
		TM helix 1	43..69	CDD:320519	4/25 (16%)
		TM helix 2	76..101	CDD:320519	9/24 (38%)
		TM helix 3	114..144	CDD:320519	8/29 (28%)
		TM helix 4	155..176	CDD:320519	6/21 (29%)
		TM helix 5	211..240	CDD:320519	9/28 (32%)
		TM helix 6	258..288	CDD:320519	8/31 (26%)
		TM helix 7	301..326	CDD:320519	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910