DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and nmur2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_002940961.1	Gene:	nmur2 / 100498226	XenbaseID:	XB-GENE-6046084	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	395	Identity:	100/395 - (25%)
Similarity:	160/395 - (40%)	Gaps:	102/395 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAI--- 99
            |.|::|.|:....:.::.:|||.||.:|..:...:|..||||:.|||::||||..||:|..:
Frog    41 SRLSLPMTLVYATIFLIGVIGNTLVCLVILKHHNMRTPTNYYLFSLAVSDLLVLLLGMPLEVYEM 105

  Fly   100 -------LASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYP-MAYSRNVRTRTA 156
                   ..:.|       |.|...|...:|..||..:..|||:||.||::| .|..::.|:| |
Frog   106 WSNYPFLFGAWG-------CYFKTVLFETVCFASILSVTTVSVERYVAIIHPFQAKLKSTRSR-A 162

  Fly   157 IFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYF-----------ATIITP 210
            :.|:...|:      |..||.......|.             ::..||           .|::.|
Frog   163 LKILVTLWI------FSILFSIPNTSTHG-------------ILLQYFPNGSLIPDSATCTVVQP 208

  Fly   211 ALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHT----GTMLRVLGAA 271
                    ..||..||:....:..:.|...:|.......:::    ||.|:    ...:.|...:
Frog   209 --------LWIYNCIIQVTSLLFYILPMGVISVLYCLMGIKL----RGDHSLEADKMSVNVQRPS 261

  Fly   272 RKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCI------ILSHLNSAVN 330
            ||   ..|:.|.::|:.|.|||.|.:......:|..| :..|....|.:      :..:|:||||
Frog   262 RK---SITKMLFVLVMVFGICWAPFHVDRLFFSFVLD-WTEPLANAFNLTHVVSGVFFYLSSAVN 322

  Fly   331 PVLYAYHLKDFRAALKNLL---LKMMGVDIDQQAEA------------------------IHRFS 368
            |::|....:.||:|.:|:|   .|.:...|..|:.|                        .||.|
Frog   323 PLIYNLLSRRFRSAFQNVLPPFFKSLKPKIPVQSLAPPKSTLILTVRNRMDSGEEGSPSFPHRTS 387

  Fly   369 VASQH 373
            |.|.|
Frog   388 VCSSH 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	50/189 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	79/307 (26%)
nmur2	XP_002940961.1	7tmA_NMU-R2	45..337	CDD:320479	85/334 (25%)
		TM helix 1	45..72	CDD:320479	8/26 (31%)
		TM helix 2	79..105	CDD:320479	14/25 (56%)
		TM helix 3	118..148	CDD:320479	12/29 (41%)
		TM helix 4	160..182	CDD:320479	7/28 (25%)
		TM helix 5	212..241	CDD:320479	5/28 (18%)
		TM helix 6	260..290	CDD:320479	10/32 (31%)
		TM helix 7	305..330	CDD:320479	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910