DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and adora3.1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_002932848.2	Gene:	adora3.1 / 100496142	XenbaseID:	XB-GENE-22169673	Length:	325	Species:	Xenopus tropicalis

Alignment Length:	362	Identity:	102/362 - (28%)
Similarity:	178/362 - (49%)	Gaps:	52/362 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILA 101
            :..|...|.|.|.|:...:::||.|||...|....|:..|.|::||||:||..||.|.:|.||:.
Frog     6 TESLTTIYIVTESLIGATAVLGNTLVIWAVRLNPALQDATFYFVVSLAIADFAVGVLVMPLAIIL 70

  Fly   102 SMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVA 166
            :|.:..:.|.|||....:::|...||..|:|:|:|||..|..|:.|...||.:.....|...|:.
Frog    71 NMEIQMHFHVCLFVCCSIIILTNASILSLLAISIDRYLRIRIPIRYRSVVRKKRIFICILFSWIL 135

  Fly   167 GTIVGFLPLFGWH--ADVNHNQ----ECLFVEVMDYNYLV-FLYFATIITPALLMLAFYTHIYRV 224
            ..:...||:|||:  :::..|:    .|.|::||..::|| |.:|..::.|..||:..||.|:.:
Frog   136 SALGALLPVFGWNHRSNLEENERDYLRCEFIKVMSLDFLVYFCFFGWVVIPLFLMVGLYTQIFYL 200

  Fly   225 IIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFF 289
            |.|              :||.:.::.|    |:..:           ..::.:...:|::::..|
Frog   201 IQK--------------NRRHNISIHQ----GKQNY-----------YSKEHRTASSLALVMFLF 236

  Fly   290 MICWIPLYTINCIKAFCP---DCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLK 351
            .:||:|:..:|||..|.|   :......:.|..|:|||.|||:||::||:.::.|:....:::.|
Frog   237 ALCWLPISIVNCISYFYPSVAENSTFQPVVLLTILLSHANSAMNPIVYAFKIRKFKYTFLSIINK 301

  Fly   352 MMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPR 388
                         |....|..:...|:|..:.:..|:
Frog   302 -------------HILCKADVNESCSIDLTLENVIPK 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	60/174 (34%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	88/285 (31%)
adora3.1	XP_002932848.2	7tm_GPCRs	11..295	CDD:391938	95/312 (30%)
		TM helix 1	13..37	CDD:341315	9/23 (39%)
		TM helix 2	46..68	CDD:341315	11/21 (52%)
		TM helix 3	82..104	CDD:341315	7/21 (33%)
		TM helix 4	127..143	CDD:341315	2/15 (13%)
		TM helix 5	172..195	CDD:341315	7/22 (32%)
		TM helix 6	223..248	CDD:341315	5/24 (21%)
		TM helix 7	263..288	CDD:341315	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000536
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24246
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010