DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and ptger3

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_002936132.2	Gene:	ptger3 / 100495208	XenbaseID:	XB-GENE-987941	Length:	381	Species:	Xenopus tropicalis

Alignment Length:	374	Identity:	81/374 - (21%)
Similarity:	149/374 - (39%)	Gaps:	97/374 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVL-VIIVFR--RERKLRRRTNYY--IVSL 83
            |...:|..:..:.:.|.|.....|.:.:.|..::||.| :::|::  |.::..|:.::.  |.||
Frog    26 AMKERDRSNMTARAEEGNTVSVAFPLSMMITGLVGNALAMLLVYKSYRNKESARKHSFLLCIGSL 90

  Fly    84 AMADLLVGALGIPFAILASMG------LPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAIL 142
            |:.|.:...|..|..|...:.      :..:.|.|.|....:.:.....:|...|::::|..||.
Frog    91 ALTDFIGQLLTSPIVISVYLSNRQWARVDPSGHLCPFFGLCMTMFGLCPLFIASAMAIERTLAIR 155

  Fly   143 YPMAYSRNVRTRTAIFIISMCWVAGTIVGF--LPLFG-----------WHADVNHNQECLFVEVM 194
            .|..||.:::.:....::...|:.  ::||  :|:.|           |         | |:...
Frog   156 TPHWYSSHMKPKATKMVLLAIWIG--VLGFALMPIIGVGQYTLQWPGTW---------C-FISTG 208

  Fly   195 DYNYLVFLYFATIITPALL-MLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVV-----QVT 253
            |...:..::||:  |.|.| :|:.:|    .....:..||.:  .|...||||.|..     ::|
Frog   209 DGEAVGNIFFAS--TYACLGLLSLFT----TFACNLSTIVAL--VSRCKRRSSTANASRQWERIT 265

  Fly   254 TPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVH---PKL 315
            ..       |::::||.             :.|||  .||.||..| .:|.......|.   ||.
Frog   266 LE-------TLIQLLGI-------------MCVLF--ACWSPLLVI-MLKMMSNHTSVEHCKPKA 307

  Fly   316 T-------------LFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLK 351
            :             |..|.|:.||..::|.:|        ..|:::||:
Frog   308 SEQNTELQKDCNFFLTAIRLASLNQILDPWVY--------LLLRHILLR 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	41/192 (21%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	71/321 (22%)
ptger3	XP_002936132.2	7tmA_PGE2_EP3	44..351	CDD:320274	77/356 (22%)
		TM helix 1	46..70	CDD:320274	6/23 (26%)
		TM helix 2	84..106	CDD:320274	7/21 (33%)
		TM helix 3	126..148	CDD:320274	3/21 (14%)
		TM helix 4	171..187	CDD:320274	3/17 (18%)
		TM helix 5	215..238	CDD:320274	7/28 (25%)
		TM helix 6	269..291	CDD:320274	10/37 (27%)
		TM helix 7	318..343	CDD:320274	7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910