DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and rxfp1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_031751332.1	Gene:	rxfp1 / 100494807	XenbaseID:	XB-GENE-985695	Length:	760	Species:	Xenopus tropicalis

Alignment Length:	343	Identity:	71/343 - (20%)
Similarity:	139/343 - (40%)	Gaps:	77/343 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DSDSPSSELN----IPYTVFEVLVAIVSIIGNVLVIIV---FRRERKLRRRTNYYIVSLAMADLL 89
            ::|..||..|    |...||..:|::::..||:.||..   .|.|.||...:   |:||..||.|
Frog   396 NTDGISSLENLLASIVQRVFVWVVSVITCFGNIFVICTRPYIRSENKLHAMS---IMSLCCADCL 457

  Fly    90 VGALGIPFAILASMGLP------RNLHA------CLFTVSLLVVLCTISIFCLVAVSVDRYWAIL 142
               :|:...::....|.      .|..|      |....||.::...:|:..|..:::::|..|:
Frog   458 ---MGVYLFVIGYFDLKYRGEYNENAQAWMDSTQCRLVGSLAILSTEVSVLLLTYLTLEKYICIV 519

  Fly   143 YPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPL-----FGWHADVN------HNQECLFVEVMDY 196
            ||....:..:.||...:| :.|:.|.::.|:||     |..:...|      |:::........|
Frog   520 YPFRCLKPGKCRTITTLI-LIWIIGFVIAFIPLSNQTFFHNYYGTNGVCFPLHSEQPESTAAQIY 583

  Fly   197 NYLVFLYFATIITPALLMLAF-YTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGH 260
            :.::||   .:...|.:::.| |:.::..|.:
Frog   584 SVIIFL---GVNLAAFIIIVFSYSSMFYSIHR--------------------------------- 612

  Fly   261 TGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCII-LSH 324
            |..|...:....|:::...:....||....:||||::.:..:...  ...:...::.:.:| :..
Frog   613 TAIMATEIHNHIKKEMTLAKRFFFIVFTDALCWIPIFILKLLSLL--QVEIPGSISSWVVIFILP 675

  Fly   325 LNSAVNPVLYAYHLKDFR 342
            :|||:||:||....:.|:
Frog   676 INSALNPILYTITTRPFK 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	44/194 (23%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	60/303 (20%)
rxfp1	XP_031751332.1	LDLa	29..64	CDD:238060
		LRRNT	105..134	CDD:214470
		PPP1R42	131..375	CDD:411060
		leucine-rich repeat	132..155	CDD:275380
		leucine-rich repeat	156..179	CDD:275380
		leucine-rich repeat	180..203	CDD:275380
		leucine-rich repeat	204..227	CDD:275380
		leucine-rich repeat	228..252	CDD:275380
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		leucine-rich repeat	349..370	CDD:275380
		7tmA_RXFP1_LGR7	410..696	CDD:320631	67/329 (20%)
		TM helix 1	412..436	CDD:320631	7/23 (30%)
		TM helix 2	445..466	CDD:320631	7/26 (27%)
		TM helix 3	490..512	CDD:320631	4/21 (19%)
		TM helix 4	534..550	CDD:320631	4/16 (25%)
		TM helix 5	582..605	CDD:320631	6/25 (24%)
		TM helix 6	631..653	CDD:320631	6/21 (29%)
		TM helix 7	664..689	CDD:320631	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910