DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and lpar3

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_031756705.1	Gene:	lpar3 / 100494791	XenbaseID:	XB-GENE-959973	Length:	361	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	89/406 - (21%)
Similarity:	158/406 - (38%)	Gaps:	95/406 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAFRYFSITDFSFEGPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIV 65
            |:...|....||.:          ..|....:.|...::| |....|.........:.|:|||..
Frog     9 MNVCHYDKRMDFFY----------NRSNSQTEDDWSGTKL-IIVLCFGACCCFFIFVSNLLVIAA 62

  Fly    66 FRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLHACLFTVS-------LLVVLC 123
            ....::......|.:.:||.||...| :...|.:..:..:.:.|     ||:       ||....
Frog    63 VVINKRFHYPFYYLLANLAAADFFAG-IAYVFLMFHTGPVSKTL-----TVNRWFLRQGLLDTSM 121

  Fly   124 TISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQEC 188
            :.|:..|:.::|:|:.:|:....:| |:..|...|:|.:.|.....:|.:|..||:...|.....
Frog   122 SASLANLLVIAVERHISIVRMRIHS-NLTKRRVTFLIFLIWAIAIFMGAVPTLGWNCICNITTCS 185

  Fly   189 LFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVT 253
            ....:...:||.| :..:.:...::||..|..|| :.:::...:::.:....::||.:...:.
Frog   186 SLAPIYSRSYLTF-WTVSNLAVFVIMLVVYLRIY-MYVQRKTNVLSPHTTGSINRRRTPIKLM-- 246

  Fly   254 TPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIP------LYTINCIKAFCPDCYV- 311
                    .|::.||||                  |:|||.|      |..:||.|     |.|
Frog   247 --------KTVMAVLGA------------------FVICWTPGMVVLLLDGLNCTK-----CGVQ 280

  Fly   312 HPKLTLFCIILSHLNSAVNPVLYAYHLKD------FRAALKNLLLKMMGVDIDQQAEAIHRFSVA 370
            |.|  .:.::|:.:||.:||::|:|  ||      |:..:..||.|..|
Frog   281 HVK--RWFLLLALMNSIMNPIIYSY--KDEEMWRTFKKMICCLLYKRRG---------------- 325

  Fly   371 SQHRLQSMDSNMRSTQ 386
              ||...|.|.:.||:
Frog   326 --HRPSRMSSTVHSTR 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	38/174 (22%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	65/289 (22%)
lpar3	XP_031756705.1	7tmA_LPAR3_Edg7	39..312	CDD:320465	71/318 (22%)
		TM helix 1	41..65	CDD:320465	5/23 (22%)
		TM helix 2	74..95	CDD:320465	7/21 (33%)
		TM helix 3	111..133	CDD:320465	4/21 (19%)
		TM helix 4	155..171	CDD:320465	4/15 (27%)
		TM helix 5	192..215	CDD:320465	5/23 (22%)
		TM helix 6	246..268	CDD:320465	10/49 (20%)
		TM helix 7	280..305	CDD:320465	9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910