DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and LOC100494508

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_002938964.2	Gene:	LOC100494508 / 100494508	-ID:	-	Length:	713	Species:	Xenopus tropicalis

Alignment Length:	353	Identity:	82/353 - (23%)
Similarity:	135/353 - (38%)	Gaps:	84/353 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DSDSPSS----ELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTN----YYIVSLAMADL 88
            :||..||    ..||...||..::|.|:..||:.||.:    |......|    ..|.||..||.
Frog   389 NSDGISSFENLLANILLRVFVWVMACVTCFGNLFVICM----RSFIVTENCQHTMSIKSLCCADC 449

  Fly    89 L-------VGALGIPFAILASMGLPRNLHA--------CLFTVSLLVVLCTISIFCLVAVSVDRY 138
            |       :||..|.|     .| ..|.||        |....||.::...:|:..|..:::::|
Frog   450 LMGFYLFCLGAFDIKF-----QG-EYNKHAQAWMESWECKLVGSLAMLSSEVSVMMLTYMTLEKY 508

  Fly   139 WAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVN---HNQECLFVE-------- 192
            ..|::|.::.|..|.:| :..::..|..|..:..:|.|.:....|   .|..|..::
Frog   509 LCIVFPFSHFRAGRGQT-LCTLTAIWGLGFFITVIPFFSYDTFGNFYGRNGVCFPLQSDSTEKYG 572

  Fly   193 VMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGR 257
            ...|:..:||        .|.:|||.|.::                   |..|....:..|
Frog   573 ARGYSVSIFL--------GLNLLAFVTIVF-------------------SYSSMFYSIHKT---- 606

  Fly   258 GGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCII- 321
            |..|...     :...|:|...:....||....:||||::.:..:.  ..:..:...:|.:.:|
Frog   607 GAKTAER-----SVLSREVTIAKRFFFIVFTDALCWIPIFLLKAVS--LTEAEIPGTITSWIVIF 664

  Fly   322 LSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            :..:|||:||:||......|:..||..|
Frog   665 ILPINSALNPILYTLTTSSFQEKLKQCL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	47/197 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	66/306 (22%)
LOC100494508	XP_002938964.2	LDLa	29..64	CDD:238060
		leucine-rich repeat	108..126	CDD:275378
		internalin_A	125..>369	CDD:380193
		leucine-rich repeat	127..150	CDD:275380
		leucine-rich repeat	151..174	CDD:275380
		leucine-rich repeat	175..198	CDD:275380
		leucine-rich repeat	199..222	CDD:275380
		leucine-rich repeat	223..247	CDD:275380
		leucine-rich repeat	248..269	CDD:275380
		leucine-rich repeat	271..293	CDD:275380
		leucine-rich repeat	294..317	CDD:275380
		leucine-rich repeat	318..341	CDD:275380
		leucine-rich repeat	342..363	CDD:275380
		7tm_GPCRs	403..688	CDD:391938	74/333 (22%)
		TM helix 1	405..429	CDD:341315	9/27 (33%)
		TM helix 2	438..459	CDD:341315	6/20 (30%)
		TM helix 3	483..505	CDD:341315	4/21 (19%)
		TM helix 4	527..543	CDD:341315	2/15 (13%)
		TM helix 5	575..598	CDD:341315	9/49 (18%)
		TM helix 6	620..645	CDD:341315	7/24 (29%)
		TM helix 7	656..681	CDD:341315	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910