DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and trhr

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_002938958.3	Gene:	trhr / 100492507	XenbaseID:	XB-GENE-992328	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	356	Identity:	95/356 - (26%)
Similarity:	151/356 - (42%)	Gaps:	73/356 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SELN-----------IPY---TVF-EVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMAD 87
            ||||           :.|   ||| .||:..:.|:||::|::|..:.:.:|..||.|:||||:||
Frog     7 SELNGTVLQKREWHGLEYQVVTVFLVVLICGLGIVGNIMVVLVVLQTKHMRTPTNCYLVSLAIAD 71

  Fly    88 LLVGALGIPFAILASMGLPRNLHA-----------CLFTVSLLVVLCTISIFCLVAVSVDRYWAI 141
            |:|         |.:.|||....:           ||....|..:....|...:.|.:|:||.||
Frog    72 LIV---------LVAAGLPNITESVYGSWVYGYIGCLCITYLQYLGINASSCSITAFTVERYLAI 127

  Fly   142 LYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECL-FVEVMDYNYLVFLYFA 205
            .:|:..........|..||...|      .|..|:           || :..::|.|..::....
Frog   128 CHPIKAQFLCTISRAKKIIVFVW------AFTSLY-----------CLMWFFLLDLNTTIYKDAT 175

  Fly   206 TIITPALLMLAFYTHIY---------------RVIIKQVRQIVTMNP-ASDLSRRSSAAVVQVTT 254
            .:.....:..:||:.||               .|:...:.:|:.:|| .||....|......||.
Frog   176 VVNCGYRVPRSFYSPIYLIDFGIFYAVPMTLATVLYGLIARILFLNPIPSDPKENSKTWKNDVTH 240

  Fly   255 PGRGGHTGTMLRVLG--AARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTL 317
            ..:..::....|...  .|.:|.|  |:.|:::|:.|...|:|..|:..:.:|....|:.....|
Frog   241 QNKAFNSKMSSRCSNNTIASRRQV--TKMLAVVVILFAFLWMPYRTLVVVNSFLSRPYLQTWFVL 303

  Fly   318 FCIILSHLNSAVNPVLYAYHLKDFRAALKNL 348
            ||.|..:||||:|||:|....:.||||.:.|
Frog   304 FCRICIYLNSAINPVIYNLMSQKFRAAFRKL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	44/179 (25%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	78/305 (26%)
trhr	XP_002938958.3	7tmA_TRH-R	26..331	CDD:320126	88/332 (27%)
		TM helix 1	28..52	CDD:320126	10/23 (43%)
		TM helix 2	61..84	CDD:320126	14/31 (45%)
		TM helix 3	99..121	CDD:320126	4/21 (19%)
		TM helix 4	144..160	CDD:320126	7/32 (22%)
		TM helix 5	189..212	CDD:320126	3/22 (14%)
		TM helix 6	265..287	CDD:320126	7/21 (33%)
		TM helix 7	299..324	CDD:320126	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910