DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and XB996286

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_017951279.1	Gene:	XB996286 / 100491805	XenbaseID:	XB-GENE-996287	Length:	376	Species:	Xenopus tropicalis

Alignment Length:	415	Identity:	94/415 - (22%)
Similarity:	157/415 - (37%)	Gaps:	117/415 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPF-AILASMGL-PRNLHAC 112
            ||.|:.::||:.::.|..|:::....|:..|.:||.:|:||.|..:|| |:...|.. ...|..|
Frog    41 LVTILGLLGNISLMYVICRQKERGNVTHILIANLAFSDVLVCAFCLPFTAVYTVMDYWVFGLSLC 105

  Fly   113 LFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNV-RTRTAIFIISMCWVAGTIVGFLPL- 175
            ..|..|.....|:|:..||.::.:||..||:|..:..:| :...|:.::   ||..:::.| ||
Frog   106 KITNFLQCASVTVSVLILVLIAFERYQLILHPTGWKPSVLQAYAAVLLV---WVIASLLAF-PLA 166

  Fly   176 ----------------FGWHADVNHNQECLFVEVMDYN-----YLVFLYFATIITPALLMLAFYT 219
                            .|:.||     :.:.||....|     |.:.|.....|.|...:|..|.
Frog   167 SSMVLTDTPNKNISKVIGFLAD-----KSVCVESWSSNQQLVAYTISLQLLQYIVPLCFILGCYL 226

  Fly   220 HIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSI 284
            .| .|.:|                                |.|.|.     .|..:.....||..
Frog   227 RI-SVHLK--------------------------------HRGAMF-----GRNDNHMRRVNLMF 253

  Fly   285 IVLF--FMICWIPLYTINCI----KAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRA 343
            :::.  |.:||:|.:..|.|    ....|.|| |..:...|.:|:.:::.||||:|.....:.:.
Frog   254 VIMVGAFAVCWLPFHIFNIIVDWHHQLIPVCY-HNLIFSLCHLLAMISTCVNPVIYGLLNSNVKR 317

  Fly   344 ALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQQEALKN 408
            .:|.|:....|                     :.:|:.....:|..|     |:       :||.
Frog   318 EVKALVQNCTG---------------------RKLDTRSAVEEPERY-----PL-------SLKQ 349

  Fly   409 SQLLPKCGVVSPCFNN---INQTVA 430
            |..||  |..|.|...   :.||::
Frog   350 SATLP--GSPSICLEGGTFLGQTLS 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	49/192 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	73/306 (24%)
XB996286	XP_017951279.1	7tm_GPCRs	34..319	CDD:391938	77/325 (24%)
		TM helix 1	35..59	CDD:341315	6/17 (35%)
		TM helix 2	68..90	CDD:341315	9/21 (43%)
		TM helix 3	106..128	CDD:341315	6/21 (29%)
		TM helix 4	149..165	CDD:341315	4/19 (21%)
		TM helix 5	203..226	CDD:341315	5/22 (23%)
		TM helix 6	247..272	CDD:341315	6/24 (25%)
		TM helix 7	287..312	CDD:341315	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910