DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and avpr2.2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_002932869.2	Gene:	avpr2.2 / 100489955	XenbaseID:	XB-GENE-1219042	Length:	364	Species:	Xenopus tropicalis

Alignment Length:	370	Identity:	75/370 - (20%)
Similarity:	138/370 - (37%)	Gaps:	89/370 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ITDFSF---EGPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVL--VAIVSIIGNVLVIIVFRR 68
            :.:|||   |.|........|:| ::..:.|.....:.|....||  :.:|:..||:.:|:|...
Frog     1 MNNFSFSMHEKPFPSREIIMTNK-SQFIERPDRSEQLAYVEISVLGVIFMVASAGNLTLILVLWN 64

  Fly    69 ERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNL-----------HACLFTVSLLVVL 122
            :||...|...:::.|::|||:|....:         ||:.:           ..|.....|.:|.
Frog    65 KRKKLSRMYVFMLHLSLADLVVAFFQV---------LPQMIWDITDVFFGPDPMCRLIRYLQLVG 120

  Fly   123 CTISIFCLVAVSVDRYWAILYPMAYSRNVR-----------------TRTAIFIISM-------- 162
            ...|.:.:|.:::||:.||.|||...:..|                 :...:||.|.
Frog   121 MFASTYMIVVMTLDRFQAICYPMVTFQKKRALWNAPICASWCISLLFSIPQVFIFSKTEIYPGIF 185

  Fly   163 -CWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVII 226
             ||..     |:..:|..|                 |:.:::.|....|..:::.....|.|.|
Frog   186 ECWAK-----FMEPWGSKA-----------------YVTWIFVAIFFIPINILIVCQIKICRTI- 227

  Fly   227 KQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMI 291
               :..:.:...|||..:....:        |....:.:..:..|..:.||.|   .:.|:.|.:
Frog   228 ---KTNIYVKQHSDLELQEQHRI--------GASRASSINCISKAMIKTVKMT---VVTVVAFFL 278

  Fly   292 CWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAY 336
            ||.|.:.::...|:..:...........::|.:|||..||.:|.|
Frog   279 CWTPFFIVHLWVAWSSEDVTEGAAFTIIMLLGNLNSCANPWIYMY 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	39/204 (19%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	61/312 (20%)
avpr2.2	XP_002932869.2	7tm_GPCRs	39..331	CDD:391938	66/331 (20%)
		TM helix 1	40..64	CDD:341315	7/23 (30%)
		TM helix 2	73..96	CDD:341315	7/31 (23%)
		TM helix 3	111..133	CDD:341315	4/21 (19%)
		TM helix 4	155..171	CDD:341315	0/15 (0%)
		TM helix 5	198..221	CDD:341315	4/39 (10%)
		TM helix 6	263..288	CDD:341315	8/27 (30%)
		TM helix 7	300..325	CDD:341315	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910