DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and gpr12

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_002931838.2	Gene:	gpr12 / 100488444	XenbaseID:	XB-GENE-5793163	Length:	340	Species:	Xenopus tropicalis

Alignment Length:	326	Identity:	82/326 - (25%)
Similarity:	138/326 - (42%)	Gaps:	46/326 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TTSKDAKDSD-SPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADL 88
            |.|.....|| ||...:| |:.:...:...|....|.:||.:......||......|.|||:|||
Frog    34 TNSSTVTTSDLSPDESVN-PWDIILCVTGTVMACENAIVIAILFYTPSLRAPMFILIGSLALADL 97

  Fly    89 LVGALGIPFAILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRT 153
            |.| ||:....:........| |.|.:..||:...:.|:..|:|:::|||.::...:.| ...||
Frog    98 LAG-LGLIVNFIVIYVFNSEL-ATLSSTGLLLAAFSASVCSLLAITLDRYLSLYNALTY-HTERT 159

  Fly   154 RTAIF-IISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAF 217
            .|..: ::.:.|.....:|.||:.||:. |.....|..:..:..|....|..:.::..| ||:..
Frog   160 LTFTYTMLILLWALCICIGLLPIMGWNC-VREPSSCSVLRPVTKNNAAVLAVSFLLLFA-LMMQL 222

  Fly   218 YTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNL 282
            |..|.|:..:..:||...:.....|:.||..                            |....|
Frog   223 YLQICRIAFRHAQQIAVQHQFMATSQASSTR----------------------------KGVSTL 259

  Fly   283 SIIVLFFMICWIP--LYTINCIKAFCPDCYVHPKLTLFCIIL-SHLNSAVNPVLYAYHLKDFRAA 344
            |:|:..|.:||||  :|::....::       |....:|::| :..||.:||::||:...|.:.:
Frog   260 SLILGTFALCWIPFAVYSLIADSSY-------PMTYTYCLVLPAACNSVINPIIYAFRNPDIQKS 317

  Fly   345 L 345
            |
Frog   318 L 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	46/168 (27%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	69/279 (25%)
gpr12	XP_002931838.2	7tmA_GPR185-like	51..318	CDD:320626	75/307 (24%)
		TM helix 1	53..77	CDD:320626	4/23 (17%)
		TM helix 2	86..107	CDD:320626	11/21 (52%)
		TM helix 3	120..142	CDD:320626	6/21 (29%)
		TM helix 4	165..181	CDD:320626	2/15 (13%)
		TM helix 5	201..224	CDD:320626	5/23 (22%)
		TM helix 6	256..278	CDD:320626	9/21 (43%)
		TM helix 7	286..311	CDD:320626	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910