DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and gpbar1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001238807.1	Gene:	gpbar1 / 100488432	XenbaseID:	XB-GENE-959591	Length:	334	Species:	Xenopus tropicalis

Alignment Length:	351	Identity:	75/351 - (21%)
Similarity:	144/351 - (41%)	Gaps:	54/351 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMG 104
            |:.|.:||.:...:..|:|     |||  .:|:....||:.:||..||||.   |:....:..|.
Frog    24 LSSPLSVFIIFSNLFIIVG-----IVF--NKKIHNTANYFFLSLLFADLLT---GVALPCIPHMR 78

  Fly   105 LPRNL--HACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAG 167
            ..:..  |.|:.:..|........:..|:.|..::|..|:||:.|......|.....:.:.|...
Frog    79 YDKKFGYHICMISYILPNFFFLSFLANLLMVHYEKYLCIVYPLRYHSIWVHRCVPLSLLIAWTLP 143

  Fly   168 TIVGFLPLFGWHA-DVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYT-HIYRVIIKQVR 230
            .:...||:.||:. |...|  |.:..|....| ::|....::.|::|.:.|.| .:..|..||::
Frog   144 LLFACLPMMGWNNWDTESN--CSYKYVFTNTY-IYLETYGVVIPSILAIVFITVKVLSVARKQLK 205

  Fly   231 QIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIP 295
            .|..::    .|.:|.|.:                   ....:.|::..:.::|:.|.|::||:|
Frog   206 NIKKLH----RSVQSQAGI-------------------ELEHQMDLRYARCIAIVSLTFLVCWVP 247

  Fly   296 LYTINCIKAFCPDCYVHP---KLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDI 357
            ...:..:.....:.|...   .|||.|:  ...::||.||:.....:::....:||..:..
Frog   248 YIAVLQVSVLAIEHYEFSWWIILTLTCV--GSGSAAVIPVILGLCHREYTELWRNLFGRYC---- 306

  Fly   358 DQQAEAIHRFSVASQHRLQSMDSNMR 383
                 ...|.|:::.|.:.|.:..::
Frog   307 -----CKRRGSLSNLHGMASKEETLQ 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	42/171 (25%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	64/282 (23%)
gpbar1	NP_001238807.1	7tmA_GPBAR1	21..291	CDD:320571	69/304 (23%)
		TM helix 1	21..46	CDD:320571	9/28 (32%)
		TM helix 2	53..78	CDD:320571	9/27 (33%)
		TM helix 3	88..118	CDD:320571	5/29 (17%)
		TM helix 4	131..154	CDD:320571	3/22 (14%)
		TM helix 5	169..198	CDD:320571	6/29 (21%)
		TM helix 6	225..255	CDD:320571	7/29 (24%)
		TM helix 7	266..291	CDD:320571	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24246
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100