DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and htr5a

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_002932543.2	Gene:	htr5a / 100487444	XenbaseID:	XB-GENE-981825	Length:	351	Species:	Xenopus tropicalis

Alignment Length:	327	Identity:	87/327 - (26%)
Similarity:	155/327 - (47%)	Gaps:	33/327 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 YTVFEVLV-------AIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILA 101
            ::||.||:       .|.:.:.||||::...|.|...|..:..:.|:|::|::|.||.:|.:::.
Frog    31 FSVFSVLILTLLAMLVIATFLWNVLVLVTILRVRTFHRVPHNLVASMAISDVMVAALVMPLSLVH 95

  Fly   102 SMG-----LPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIIS 161
            .:.     |.|.|  |...:|..|:.||.||:.:.|:::||||:|...:.|:...|.|.:..:|.
Frog    96 ELNDRRWRLGRVL--CHIWISFDVLCCTASIWNVTAIALDRYWSITRHLEYTLKTRKRISNIMIL 158

  Fly   162 MCWVAGTIVGFLPLFGW---HADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIY- 222
            :.|:...::...|||||   :::|  |:||...:  :.:|.:|..|.....|..::|..|..||
Frog   159 LTWLLSAVISLSPLFGWGETYSEV--NEECQVSQ--EPSYTIFSTFGAFYLPLCVVLFVYWKIYK 219

  Fly   223 ----RVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAA--RKRDVKATQN 281
                |:..|:...|..|....::...|....:..|.    .|.....:..|..  .:::.||...
Frog   220 AAKFRIGSKKTNTITPMPEVIEVKEASHQPQMVFTV----RHATVTFQTDGDTWREQKEKKAALM 280

  Fly   282 LSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALK 346
            :.|::..|::||||.:....|...| .|.:.|......:.|.:.||..||::|....|::..|.:
Frog   281 VGILIGVFVLCWIPFFITELINPLC-SCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFR 344

  Fly   347 NL 348
            ||
Frog   345 NL 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	51/175 (29%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	77/290 (27%)
htr5a	XP_002932543.2	7tmA_5-HT5	36..343	CDD:320451	82/317 (26%)
		TM helix 1	37..63	CDD:320451	6/25 (24%)
		TM helix 2	70..96	CDD:320451	7/25 (28%)
		TM helix 3	109..139	CDD:320451	12/29 (41%)
		TM helix 4	151..172	CDD:320451	3/20 (15%)
		TM helix 5	191..220	CDD:320451	8/28 (29%)
		TM helix 6	272..302	CDD:320451	8/29 (28%)
		TM helix 7	311..336	CDD:320451	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910