DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and gpr6

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_017949566.1	Gene:	gpr6 / 100486442	XenbaseID:	XB-GENE-997133	Length:	327	Species:	Xenopus tropicalis

Alignment Length:	327	Identity:	78/327 - (23%)
Similarity:	140/327 - (42%)	Gaps:	64/327 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SSELNIPYTVF-----EVLVAIVSII---GNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGAL 93
            |.||:..::||     ::::.|...|   .|.:|:.:......||......|.|||.||||.|
Frog    25 SLELSAFFSVFTINPWDIMLCISGTIIACENAIVVAIIFYTPTLRTPMFVLIGSLATADLLAG-- 87

  Fly    94 GIPFAILASMGLPRNLHA---CLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRT 155
               |.::.:......:.:   .|.||..||...|.|:..|:|::||||.::...:.||..   :|
Frog    88 ---FGLILNFVFQYVIQSETISLITVGFLVASFTASVSSLLAITVDRYLSLYNALTYSSE---KT 146

  Fly   156 AIFI---ISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFL---YFATIITPALLM 214
            .::|   :.:.|.....:|.||:.||:. ::.:..|..|:.:..:.:..|   :|...|    ||
Frog   147 ILWIHMMLVVTWGVSLCLGLLPVLGWNC-LDDDSSCSIVKPLTKSNVTLLSTSFFFIFI----LM 206

  Fly   215 LAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKAT 279
            |..|..|.:::.:...||.       |.:....|...|.|.                     |..
Frog   207 LHLYIKICKIVCRHAHQIA-------LQQHFLTASHYVATK---------------------KGV 243

  Fly   280 QNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIIL-SHLNSAVNPVLYAYHLKDFRA 343
            ..|:||:..|...|:| :.|.|:..    .:.:|.:..:..:| :..||.:||::|||..::.:.
Frog   244 STLAIILGTFGASWLP-FAIYCVVG----DHDYPSVYTYATLLPATYNSMINPIIYAYRNQEIQR 303

  Fly   344 AL 345
            ::
Frog   304 SM 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	48/179 (27%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	68/285 (24%)
gpr6	XP_017949566.1	7tmA_GPR6	38..305	CDD:320628	73/312 (23%)
		TM helix 1	39..65	CDD:320628	4/25 (16%)
		TM helix 2	72..97	CDD:320628	10/29 (34%)
		TM helix 3	106..136	CDD:320628	13/29 (45%)
		TM helix 4	148..168	CDD:320628	3/19 (16%)
		TM helix 5	187..216	CDD:320628	8/32 (25%)
		TM helix 6	237..267	CDD:320628	11/51 (22%)
		TM helix 7	273..298	CDD:320628	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910