DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and gpr142

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_031750683.1	Gene:	gpr142 / 100486047	XenbaseID:	XB-GENE-990349	Length:	338	Species:	Xenopus tropicalis

Alignment Length:	345	Identity:	82/345 - (23%)
Similarity:	143/345 - (41%)	Gaps:	65/345 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNY-YIVSL 83
            ||......:......||.....||...:.:|:.: .:..|:|..:...|.....::::| |:::|
Frog    10 PLQPGVMDEGNVSDPSPCVLGIIPVIYYSILLCL-GLPVNMLTAVALSRLASRTKKSSYSYLLAL 73

  Fly    84 AMADLLVGALGIPFA--ILASMGLPRNLHACLFTVSLLVVLCT--ISIFCLVAVSVDRYWAILYP 144
            .::|:| ..:.|.|.  ||.:..|.|.:.:.|..|..::...:  .||:..|.::||||.|:.||
Frog    74 TISDIL-SQIFIIFVGFILQTAILHRKVPSTLIHVVSVLEFSSNHASIWVTVILTVDRYVALCYP 137

  Fly   145 MAY---SRNVRTRTAI-FIISMCWVAGTIVGFLPLFGWHADVNHNQEC--LFVEVMDYNYLVFLY 203
            :.|   |...|||..| |:....:|.|     :| |.|.:||..:...  |...::.:.:...:|
Frog   138 LQYRSFSYPERTRRVIVFVFLSSFVTG-----VP-FYWWSDVWRDPRTPGLLDLILKWTHCFIIY 196

  Fly   204 FATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVL 268
            |   |...:.::.....|||                 |.:|:.:...|:    |.|.|..:|  |
Frog   197 F---IPCTIFLITNSVIIYR-----------------LRKRTGSKKCQL----RNGKTTAIL--L 235

  Fly   269 GAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFC----PDCYVHPKLTLFCIILSHLNSAV 329
            |               |...|.:.|.|...:..|..:.    .|..||..:.: ..:|:.||:||
Frog   236 G---------------ITSVFAVLWAPRTIVIIIHMYVSSVNKDWKVHLAMDI-GNMLALLNTAV 284

  Fly   330 NPVLYAYHLKDFRAALKNLL 349
            |..||.:..:.||..::.:|
Frog   285 NFFLYCFVNRRFRDTVREIL 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	44/178 (25%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	70/290 (24%)
gpr142	XP_031750683.1	7tmA_GPR142	31..300	CDD:320257	77/318 (24%)
		TM helix 1	33..57	CDD:320257	4/24 (17%)
		TM helix 2	67..89	CDD:320257	7/22 (32%)
		TM helix 3	106..128	CDD:320257	4/21 (19%)
		TM helix 4	151..167	CDD:320257	5/21 (24%)
		TM helix 5	185..208	CDD:320257	3/25 (12%)
		TM helix 6	231..253	CDD:320257	7/38 (18%)
		TM helix 7	268..293	CDD:320257	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910