DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and gpr27

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_012817202.1	Gene:	gpr27 / 100485839	XenbaseID:	XB-GENE-978905	Length:	370	Species:	Xenopus tropicalis

Alignment Length:	336	Identity:	79/336 - (23%)
Similarity:	143/336 - (42%)	Gaps:	53/336 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPF---AILASMGLPRNLHA 111
            ::|.||:.||:|...:..:::.|.|...|.::.|.:.||:...|..|.   :|.:......:..:
Frog    31 IIACVSLAGNLLFAFIALKDKNLHRAPYYLMLDLCVGDLIRSLLCFPLVLKSISSGSQWTYSKRS 95

  Fly   112 CLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLF 176
            |.......|:||..:.|.|:::|:.||.||.:...|.:.:.......:|||.|:..|.:...|:|
Frog    96 CRIMAFGAVLLCFHAAFMLLSISLTRYMAIAHHRFYCKRMTGWACAIVISMAWILSTAMALPPVF 160

  Fly   177 --GWHADVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFY---TH-IYRVIIKQVRQIVTM 235
              |.:..:....:|.|    ::.|:.    |......||||||.   || ||..::..:.....|
Frog   161 EVGTYKFIREEDQCTF----EHRYVK----ANDSLGFLLMLAFIVGATHFIYMKLLFFIYDHRKM 217

  Fly   236 NPAS---DLSRRSS---------AAVVQVTTPGRGGHTGTMLRVLGAAR------------KRDV 276
            .||.   .:|:..|         ||...:...|||....|::.:..:.:            |::.
Frog   218 KPAQLTPAISQNWSFHGPGAAGQAAANWIAGFGRGPTPPTLVGMRQSTQGHIKRLVVLEEFKQEK 282

  Fly   277 KATQNLSIIVLFFMICWIPLYTINC-IKAF-----CPDCYVHPKLTLFCIILSHLNSAVNPVLYA 335
            :..:...:|...|::.|.| |.:.| ::.|     .|..|    ||. .:.|:...:.|||::..
Frog   283 RLCKMFYVITFLFLVFWAP-YLLACYLRVFLKASSLPQGY----LTT-AVWLTFAQAGVNPIVCL 341

  Fly   336 YHLKDFRAALK 346
            ...|:.|.:|:
Frog   342 LLNKEVRMSLR 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	45/175 (26%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	73/314 (23%)
gpr27	XP_012817202.1	7tmA_SREB-like	25..351	CDD:320134	78/333 (23%)
		TM helix 1	25..50	CDD:320134	6/18 (33%)
		TM helix 2	57..82	CDD:320134	6/24 (25%)
		TM helix 3	96..126	CDD:320134	10/29 (34%)
		TM helix 4	140..160	CDD:320134	6/19 (32%)
		TM helix 5	181..210	CDD:320134	11/32 (34%)
		TM helix 6	279..309	CDD:320134	7/30 (23%)
		TM helix 7	319..344	CDD:320134	7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910