DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and drd1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_017947694.2	Gene:	drd1 / 100485463	XenbaseID:	XB-GENE-6035431	Length:	451	Species:	Xenopus tropicalis

Alignment Length:	462	Identity:	127/462 - (27%)
Similarity:	203/462 - (43%)	Gaps:	96/462 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TTSKDAKDSDSPSSELNIPYTV----FEVLVAIVSIIGNVLVIIVFRRERKLRRR-TNYYIVSLA 84
            |.:..:.|.|...:|.:..:.|    |..::.:.:::||.||.....|.|.||.: ||::::|||
Frog     2 TLNITSMDEDVLLAERDSSFRVLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLA 66

  Fly    85 MADLLVGALGIPFAILASMG--LPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAY 147
            ::||||..|.:|:..:|.:.  .|.... |...|:..::..|.||..|..:||||||||..|..|
Frog    67 VSDLLVAVLVMPWKAVAEIAGFWPFGTF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRY 130

  Fly   148 SRNVRTRTAIFIISMCWVAGTIVGFLPL-FGWHA-------DVNHNQECLFVEVMD-------YN 197
            .|.:..:.|..:||:.|....::.|:|: ..||.       |:|..   |....||       ..
Frog   131 ERKMTPKVAFIMISVAWTLSILISFIPVQLNWHKAKTTSFFDLNIT---LHGRTMDNCDSSLNRT 192

  Fly   198 YLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTG 262
            |.:.....:...|..:|:..||.|||:..||:|:|      |.|.|   |||.........|:..
Frog   193 YAISSSLISFYIPVAIMIVTYTRIYRIAAKQIRRI------SALER---AAVHAKNCQNSTGNRN 248

  Fly   263 TM-----LRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTL----- 317
            ::     ...|..:.||:.|..:.||:|:..|:.||:|.:.:|||..||     .|.||.
Frog   249 SLDCQQPESSLKTSFKRETKVLKTLSVIMGVFVCCWLPFFILNCIVPFC-----DPSLTTSGTEP 308

  Fly   318 FCII---------LSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQH 373
            |||.         ....||::||::||:: .|||.|..|||             ..:|....|.:
Frog   309 FCISSTTFDVFVWFGWANSSLNPIIYAFN-ADFRKAFSNLL-------------GCYRLCPTSNN 359

  Fly   374 RLQSMDSNMRST-------QPRLYV-GEYSPIWL------RQQQEALKN------SQLLPKCGVV 418
            .::::..|....       :|:..: .|.:.::|      ..:.|.||.      |:.|.|   :
Frog   360 VIETVSINNNGAVVYSCQQEPKGSIPNECNLVYLIPHAIICPEDEVLKKEDESGLSKSLEK---M 421

  Fly   419 SPCFNNI 425
            ||.|:.|
Frog   422 SPAFSGI 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	55/185 (30%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	96/312 (31%)
drd1	XP_017947694.2	7tmA_D1A_dopamine_R	22..344	CDD:320443	103/340 (30%)
		TM helix 1	25..49	CDD:320443	5/23 (22%)
		TM helix 2	59..81	CDD:320443	10/21 (48%)
		TM helix 3	96..118	CDD:320443	5/21 (24%)
		TM helix 4	141..157	CDD:320443	4/15 (27%)
		TM helix 5	191..214	CDD:320443	3/22 (14%)
		TM helix 6	270..292	CDD:320443	7/21 (33%)
		TM helix 7	313..338	CDD:320443	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910