DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and mtnr1c

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_031747846.1	Gene:	mtnr1c / 100485432	XenbaseID:	XB-GENE-985295	Length:	429	Species:	Xenopus tropicalis

Alignment Length:	481	Identity:	102/481 - (21%)
Similarity:	188/481 - (39%)	Gaps:	130/481 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLV 90
            |.:||:  |..|..|.....|..:...||.::||:|||:...|.:||:...|.::|||::|||:|
Frog    19 TEQDAQ--DGASQGLTSALAVVLIFTIIVDVLGNMLVILSVLRNKKLQNAGNLFVVSLSVADLVV 81

  Fly    91 GALGIPFAILA------SMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSR 149
            .....|..::|      ::|   |:| |..:..|:.:....|:|.:.|::::||..|.:.:.|.:
Frog    82 AVYPYPVILIAIFQNGWTLG---NIH-CQISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDK 142

  Fly   150 NVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQ---ECLFVEVMDYNYLVFLYFATIITPA 211
            ....::....:.:.|:. ||:..:|.| :...:.::.   .|.|.:.:..:|.:.:.....|.|.
Frog   143 LFNQKSTWCYLGLTWIL-TIIAIVPNF-FVGSLQYDPRIFSCTFAQTVSSSYTITVVVVHFIVPL 205

  Fly   212 LLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDV 276
            .::...|..|: |::.||:..|..:            ..|..||                  .|:
Frog   206 SVVTFCYLRIW-VLVIQVKHRVRHD------------FKQKLTP------------------TDL 239

  Fly   277 KATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLT--LFCI--ILSHLNSAVNPVLYAYH 337
            :....:.::.:.|.:||.||..|....|..| .:|.||:.  ||.:  .:::.||.:|.|:|...
Frog   240 RNFLTMFVVFVLFAVCWAPLNFIGLAVAINP-LHVAPKIPEWLFVVSYFMAYFNSCLNAVIYGLL 303

  Fly   338 LKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQ 402
            .::||...|.:|:.::                  ..||..:|::...|
Frog   304 NQNFRKEYKRILMSLL------------------TPRLLFLDTSRGGT----------------- 333

  Fly   403 QEALKNSQLLPKCGVVSPCFNNINQTVAAVASVTTDLEREMWNIVEASSGAELGETSYEFPSPAP 467
             |.:|:..        ||...|.||.                                :.|:.|
Frog   334 -EGMKSKP--------SPAVTNNNQA--------------------------------DMPANA- 356

  Fly   468 GSQRSSERNSSSTVPPAPPAPAKPSV 493
            .|.|.|.||.:..|....|..|:.::
Frog   357 RSLRLSRRNGAKMVIMTRPRKAQIAI 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	43/176 (24%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	67/288 (23%)
mtnr1c	XP_031747846.1	7tm_GPCRs	33..311	CDD:421689	73/315 (23%)
		TM helix 1	34..60	CDD:410628	8/25 (32%)
		TM helix 2	67..92	CDD:410628	9/24 (38%)
		TM helix 3	105..135	CDD:410628	7/29 (24%)
		TM helix 4	147..169	CDD:410628	5/23 (22%)
		TM helix 5	189..218	CDD:410628	5/29 (17%)
		TM helix 6	236..266	CDD:410628	8/47 (17%)
		TM helix 7	279..304	CDD:410628	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910