DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and htr1e

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_002933964.1	Gene:	htr1e / 100380026	XenbaseID:	XB-GENE-965113	Length:	362	Species:	Xenopus tropicalis

Alignment Length:	355	Identity:	91/355 - (25%)
Similarity:	157/355 - (44%)	Gaps:	70/355 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VFEVLVAIVSIIGNVL---VIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILA------ 101
            :..:.:||::|:..||   ||:.....:||.:..||.|.|||:.|.||..|.:|.:|..
Frog    21 LISLTLAIITILTTVLNSAVILAICTTKKLHQPANYLICSLAVTDFLVAILVMPLSITYIVMDTW 85

  Fly   102 SMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVA 166
            ::|..    .|...:|:.:..||.||..|..:::||||||...:.|:|....:.|..:|...|..
Frog    86 TLGYV----ICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTVKRAGIMILTVWTI 146

  Fly   167 GTIVGFLPLFGW--HADVNHNQECLFVEVMDYNYLVFLYFAT---IITPALLMLAFYTHIYRVI- 225
            ...:...||| |  |.::|...:|    ::.:::|::..::|   ...|..|:|..|..||...
Frog   147 SVFISIPPLF-WRNHHNINIPSKC----IIQHDHLIYTIYSTCGAFYIPLTLILILYYRIYHAAK 206

  Fly   226 ---------------------------IKQ---VRQIVTMNPASDLSRRSSAAVVQVTTPGRGGH 260
                                       :.|   |.:..|.:|.::..:.:::    |.||.....
Frog   207 NLYQKRGSSRHLSNRSNDSQNSFAHCKLTQTFCVSEFSTSDPTTEFEKMNAS----VRTPPYDND 267

  Fly   261 T---GTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPD---CYVHPKLTLFC 319
            .   |...:.:.::|:|  ||.:.|.:|:..|::.|:|.:    ||.....   |.|.|::..|.
Frog   268 IDIFGDRQQQISSSRER--KAARILGLILGAFILSWLPFF----IKELVVGIQLCTVSPEVADFL 326

  Fly   320 IILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            ..|.::||.|||:||.....||:.|.|.|:
Frog   327 TWLGYVNSLVNPLLYTSFNDDFKLAFKKLI 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	53/181 (29%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	81/326 (25%)
htr1e	XP_002933964.1	7tmA_5-HT1E	20..352	CDD:320457	88/349 (25%)
		TM helix 1	21..47	CDD:320457	7/25 (28%)
		TM helix 2	54..80	CDD:320457	12/25 (48%)
		TM helix 3	92..122	CDD:320457	12/29 (41%)
		TM helix 4	134..156	CDD:320457	4/21 (19%)
		TM helix 5	175..204	CDD:320457	8/28 (29%)
		TM helix 6	281..311	CDD:320457	11/35 (31%)
		TM helix 7	320..345	CDD:320457	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910