DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and lgr6

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_017209265.2	Gene:	lgr6 / 100330212	-ID:	-	Length:	962	Species:	Danio rerio

Alignment Length:	519	Identity:	96/519 - (18%)
Similarity:	173/519 - (33%)	Gaps:	202/519 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DFSFEGP-LLPLHAATTSKDAKDSDSPSSELNI----------------PY----TVFEV----- 49
            ||..:.| |.|:|    :.:..|.|....:|.|                |:    .:|:.
Zfish   498 DFQKKSPSLFPIH----TDNNYDLDLEEFQLAIEESKLQTSIQCTPIPGPFKPCDNLFDSWVVRL 558

  Fly    50 ---LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVG-------------------- 91
               |:::||::||.|:|:.............:.|.:::.|:||.|
Zfish   559 GMWLISLVSLMGNSLLILTVFTSPSYLSPVKFIIGTISGANLLTGLCTGTLALVDARTFGEFALH 623

  Fly    92 -----------ALGIPFAILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPM 145
                       |:|. .::|||.|      :.|| ::|..|.|::|:.|              ..
Zfish   624 GAQWEMGAGCRAVGF-LSVLASEG------SILF-LTLAAVQCSVSVSC--------------AR 666

  Fly   146 AYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDYNYLVFLYFAT-IIT 209
            ||.::....:.......|......|..|||.|                      |..|.|| :..
Zfish   667 AYGKSPSLGSVRAAAVACLALSLAVAALPLIG----------------------VGEYGATPLCM 709

  Fly   210 PALL------MLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVL 268
            |:.|      .|.|..           .::.||....|       |:          |||.:::.
Zfish   710 PSPLPDGEPSTLGFMV-----------ALIMMNSLCFL-------VI----------TGTYIKLY 746

  Fly   269 GAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYV--HPKLTLF----------CII 321
            ....|.|..:..:.::|.   .:.|: ::| ||: .:||..::  ...|:||          .::
Zfish   747 WDLMKGDFDSIWDCAMIK---HVAWL-IFT-NCL-LYCPVAFLTFSSLLSLFPVSEEVVKSVVLV 805

  Fly   322 LSHLNSAVNPVLYAYHLKDFRAALKNLLLK-----------MMGVDIDQQA-------------- 361
            |..|.:::||:||......||..::.||.:           .:.||.::.:
Zfish   806 LLPLPASINPLLYLLFNPHFREDMRLLLSRAHLNHDRNLDSFVSVDTEKSSYDSTQALVSFATEA 870

  Fly   362 ------------EAIHRFSVASQHRLQSMDSNMRSTQPRLYVGE----YSPIWLRQQQEALKNS 409
                        |.:.||:......|......|:.:..|...||    .:|..:.::||.:::|
Zfish   871 DGVFESLSVPNPETVARFTCPPSVALIPCQMQMKPSTDRENTGENLIRSAPGLIAKEQEHIRSS 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	40/205 (20%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	61/325 (19%)
lgr6	XP_017209265.2	LRRNT	28..64	CDD:214470
		PLN00113	53..>448	CDD:331614
		leucine-rich repeat	62..85	CDD:275380
		leucine-rich repeat	86..109	CDD:275380
		leucine-rich repeat	110..133	CDD:275380
		leucine-rich repeat	134..157	CDD:275380
		leucine-rich repeat	158..181	CDD:275380
		leucine-rich repeat	182..205	CDD:275380
		leucine-rich repeat	206..229	CDD:275380
		leucine-rich repeat	230..252	CDD:275380
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..298	CDD:275380
		leucine-rich repeat	324..338	CDD:275378
		leucine-rich repeat	348..369	CDD:275380
		leucine-rich repeat	370..393	CDD:275380
		leucine-rich repeat	394..417	CDD:275380
		leucine-rich repeat	418..438	CDD:275380
		7tmA_LGR6	554..829	CDD:320484	68/352 (19%)
		TM helix 1	555..581	CDD:320484	7/25 (28%)
		TM helix 2	588..613	CDD:320484	5/24 (21%)
		TM helix 3	633..663	CDD:320484	12/37 (32%)
		TM helix 4	675..697	CDD:320484	4/21 (19%)
		TM helix 5	719..748	CDD:320484	9/56 (16%)
		TM helix 6	757..787	CDD:320484	7/35 (20%)
		TM helix 7	797..822	CDD:320484	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910