DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and adrb2

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001116897.2	Gene:	adrb2 / 100144654	XenbaseID:	XB-GENE-494302	Length:	419	Species:	Xenopus tropicalis

Alignment Length:	356	Identity:	98/356 - (27%)
Similarity:	168/356 - (47%)	Gaps:	34/356 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ITDFSFEGPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLR 73
            :|...:....|....:..|..:..||.|.....:...:....:.:|.::||||||....:.::|:
Frog     5 VTASPYPNSTLEQLVSNVSNTSNASDKPGDAWMVGMGIIMSCIVLVIVLGNVLVITAIAKFQRLQ 69

  Fly    74 RRTNYYIVSLAMADLLVGALGIPF---AILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSV 135
            ..|||:|.|||.||||:|.:.:||   :|:....:..|.. |.|..|:.::..|.||..|..::|
Frog    70 TVTNYFITSLACADLLMGLIVVPFGASSIILDTWVFNNFW-CEFWTSVDILCVTASIETLCVIAV 133

  Fly   136 DRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLF-GWH----ADVNH---NQECLFVE 192
            |||:||..|..|...:....|..:|.:.||..|:..|||:: .|:    ....|   :..|.|.
Frog   134 DRYFAITSPFRYQSLLTKCKARIVILLVWVVSTLTSFLPIYMHWYRIEEESALHCYDDPSCCFF- 197

  Fly   193 VMDYNYLVFLYFATIIT---PALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSR-RSSAAVVQVT 253
               :....:...::||:   |.::|:..|..:::...||:::|       |.|. |......|..
Frog   198 ---FTNPAYAISSSIISFYLPLVVMIFVYARVFQEAKKQLKKI-------DKSEGRFHNQNNQQD 252

  Fly   254 TPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPKLTLF 318
            |.|:.|:..|....|     ::.||.:.|.||:..|.:||:|.:.:|.::....| ::..|:..|
Frog   253 TNGKQGNKRTSKFWL-----KEHKALKTLGIIMGTFTLCWLPFFIVNIVQVMHKD-FIPVKVYNF 311

  Fly   319 CIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349
            ...:.::|||.||::|. ...|||...:.||
Frog   312 LNWVGYVNSAFNPLIYC-RSPDFRYTFQELL 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	56/181 (31%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	85/290 (29%)
adrb2	NP_001116897.2	7tmA_Beta2_AR	38..337	CDD:341355	90/317 (28%)
		TM helix 1	39..65	CDD:341355	7/25 (28%)
		TM helix 2	72..99	CDD:341355	14/26 (54%)
		TM helix 3	110..140	CDD:341355	12/29 (41%)
		TM helix 4	152..175	CDD:341355	8/22 (36%)
		TM helix 5	200..232	CDD:341355	5/31 (16%)
		TM helix 6	267..297	CDD:341355	11/34 (32%)
		TM helix 7	306..331	CDD:341355	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910