DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and galr1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001107355.1	Gene:	galr1 / 100135180	XenbaseID:	XB-GENE-5797254	Length:	351	Species:	Xenopus tropicalis

Alignment Length:	385	Identity:	97/385 - (25%)
Similarity:	159/385 - (41%)	Gaps:	125/385 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DAKDSDSPSS---------ELNIPYTVFEVLVAIVSIIGNVLVIIVFRRER--KLRRRTNYYIVS 82
            |...|:.||:         :..|...||.::.|: .::||.|||.|..|.:  |.|..||.:|::
Frog    17 DPNSSEVPSAVKPLLGIGIDNVITLVVFGMIFAL-GVLGNSLVITVLARNKPGKPRSTTNIFILN 80

  Fly    83 LAMADLLVGALGIPFA---------ILASMGLPRNLHACLFTVSLLVVLCTISIFCLVAVSVDRY 138
            |::|||......|||.         :|.:. :.:.:| ..||||:||     |||.|.|:|||||
Frog    81 LSIADLAYLLFCIPFQSTVYVLPTWVLGAF-ICKFIH-YFFTVSMLV-----SIFTLSAMSVDRY 138

  Fly   139 WAILYPMAYSRNVRTRTAIFIISMCWV------------AGTIVGFLPLFGWHADVNHNQE---- 187
            .||::....|....:|.|:..:.:.|:            .|.:......|.|.:..|..|:
Frog   139 VAIVHSRRSSAIRVSRNALVGVIVIWILSIAMASPVAYNQGLVYKNNQTFCWESWPNAQQKRIYV 203

  Fly   188 -CLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRSSAAVVQ 251
             |.||    :.||:         |.||:...|..:...:.|::|         ::|::|.|:
Frog   204 VCTFV----FGYLL---------PLLLISFCYAKVLNHLHKKLR---------NMSKKSEAS--- 243

  Fly   252 VTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINC--------------- 301
                                 |:  |..|.:.::|:.|.|.|:|.:.|:.
Frog   244 ---------------------KK--KTAQTVLVVVVVFGISWLPHHVIHLWVEYGSFPLTQASFV 285

  Fly   302 --IKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQ 359
              |.|.|               |::.||:|||::||:..::||.|.|.:....:|.|.:|
Frog   286 FRIVAHC---------------LAYSNSSVNPIIYAFLSENFRKAYKQVFKCQIGCDSNQ 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	58/195 (30%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	80/320 (25%)
galr1	NP_001107355.1	7tmA_Gal1_R	38..316	CDD:320226	88/348 (25%)
		TM helix 1	39..65	CDD:320226	10/26 (38%)
		TM helix 2	74..100	CDD:320226	10/25 (40%)
		TM helix 3	112..142	CDD:320226	18/35 (51%)
		TM helix 4	154..174	CDD:320226	3/19 (16%)
		TM helix 5	199..228	CDD:320226	9/41 (22%)
		TM helix 6	242..272	CDD:320226	10/55 (18%)
		TM helix 7	284..309	CDD:320226	11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910