DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdoR and adora1

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001106540.1	Gene:	adora1 / 100127730	XenbaseID:	XB-GENE-944026	Length:	326	Species:	Xenopus tropicalis

Alignment Length:	315	Identity:	108/315 - (34%)
Similarity:	177/315 - (56%)	Gaps:	42/315 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLP 106
            :.|.|||.::|::|::||:|||......:.||..|.::|||||:||:.||||.||.||:.|:||.
Frog     8 VVYIVFEAVIALISVLGNILVIWAVIVNQALRDTTFFFIVSLAVADIAVGALVIPLAIIISIGLE 72

  Fly   107 RNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVG 171
            ...::||..|.::::|...||..|:|::||||..:..|.:|...|..|.|...|:.|||...:||
Frog    73 TEFYSCLMVVCIVLILTQSSILALLAIAVDRYLRVRIPTSYRSVVTARRAGIAITGCWVLSFLVG 137

  Fly   172 FLPLFGWHADVNH--NQE----------CLFVEVMDYNYLV-FLYFATIITPALLMLAFYTHIYR 223
            .:|:|||: :||:  |::          |.|..|:...|:| |.:|..::.|..|||..|..::.
Frog   138 LVPMFGWN-NVNNLKNEQNSTESGLIITCQFETVISMEYMVYFNFFVWVLPPLFLMLIIYLEVFY 201

  Fly   224 VIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLF 288
            :|.||:.:.|..|                   .:..|     :..|    :::|..::|::|:|.
Frog   202 LIQKQLNKKVCAN-------------------SKDPH-----KYYG----KELKIAKSLALILLL 238

  Fly   289 FMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRA 343
            |.:.|:||:|:|||..||..|.....:|...|.|:|.|||:||::||:.::.|::
Frog   239 FALSWLPLHTLNCITLFCKTCKTPMIITYVAIFLTHGNSAMNPIVYAFRIEKFQS 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	70/180 (39%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	99/288 (34%)
adora1	NP_001106540.1	7tmA_Adenosine_R_A1	9..295	CDD:341323	108/314 (34%)
		TM helix 1	9..35	CDD:341323	11/25 (44%)
		TM helix 2	42..69	CDD:341323	16/26 (62%)
		TM helix 3	78..108	CDD:341323	12/29 (41%)
		TM helix 4	122..140	CDD:341323	7/17 (41%)
		TM helix 5	173..203	CDD:341323	9/29 (31%)
		TM helix 6	223..253	CDD:341323	12/33 (36%)
		TM helix 7	263..288	CDD:341323	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000536
OrthoInspector	1	1.000	-	-		otm48071
Panther	1	1.100	-	-	O	PTHR24246
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X919
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010