DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdoR and adrb2b

DIOPT Version :9

Sequence 1:	NP_651772.1	Gene:	AdoR / 43583	FlyBaseID:	FBgn0039747	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001082940.2	Gene:	adrb2b / 100037315	ZFINID:	ZDB-GENE-070410-32	Length:	409	Species:	Danio rerio

Alignment Length:	351	Identity:	90/351 - (25%)
Similarity:	156/351 - (44%)	Gaps:	63/351 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DSDSPSSELNIPYTVFEV--------LVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADL 88
            ::.||.|.....|:..||        ::.:|.:.||.|||....|.::|:..|||:|.|||.|||
Zfish    23 NASSPVSLSVSEYSDAEVVLISILIGILVLVIVFGNALVISAIVRFQRLQTVTNYFISSLACADL 87

  Fly    89 LVGALGIPFAILASMGLPRNLH----ACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSR 149
            ::|.:.:||.  |...|....|    .|.|..:..|:..|.||..|..:::|||.||::|:.|..
Zfish    88 VMGLMVVPFG--ACYILLNTWHFGNFFCEFWTATDVLCVTASIETLCVIALDRYIAIMWPLRYQS 150

  Fly   150 NVRTRTAIFIISMCWVAGTIVGFLPLF--GWHADVNHNQECLFVEV-MDYN----YLVFLYFATI 207
            .:..|.|..::...|....::.|||:.  .|.:|......||.... .|:|    |.|.....:.
Zfish   151 MLTKRKACGMVIGVWAVAALISFLPIHMEWWVSDEPEALSCLEEPTCCDFNTNAAYAVTSSIISF 215

  Fly   208 ITPALLMLAFYTHIYRVIIKQVRQI-----------VTMNPASDLSRRSSAAVVQVTTPGRGGHT 261
            ..|.::|...|:.:::...:|:::|           ::....:::..|.:...:
Zfish   216 YIPLVIMAFVYSRVFQEARRQLQKIDRIEGRIRTQSLSTQEGNEIKNRRTKFCM----------- 269

  Fly   262 GTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCP-DCYVHPKLTLFCII--LS 323
                        :|.||.:.|.||:..|.:||:|.:.:|.:.|... |..:.|    |.|:  :.
Zfish   270 ------------KDHKALKTLGIIMGTFTLCWLPFFVLNVVAAIWKMDNIMLP----FRILNWIG 318

  Fly   324 HLNSAVNPVLYAYHLKDFRAALKNLL 349
            :.|||.||::|. ...:||.|.:.:|
Zfish   319 YANSAFNPLIYC-RSPEFRCAFQEIL 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdoR	NP_651772.1	7tm_4	52..>220	CDD:304433	55/178 (31%)
AdoR	NP_651772.1	7tm_1	58..334	CDD:278431	78/300 (26%)
adrb2b	NP_001082940.2	7tm_GPCRs	41..339	CDD:333717	82/327 (25%)
		TM helix 1	43..67	CDD:320095	6/23 (26%)
		TM helix 2	76..98	CDD:320095	12/23 (52%)
		TM helix 3	114..136	CDD:320095	6/21 (29%)
		TM helix 4	159..175	CDD:320095	2/15 (13%)
		TM helix 5	204..227	CDD:320095	4/22 (18%)
		TM helix 6	272..297	CDD:320095	9/24 (38%)
		TM helix 7	308..333	CDD:320095	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910