DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tpi and tpi-1

DIOPT Version :9

Sequence 1:	NP_788764.1	Gene:	Tpi / 43582	FlyBaseID:	FBgn0086355	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	NP_001366651.1	Gene:	tpi-1 / 174844	WormBaseID:	WBGene00006601	Length:	247	Species:	Caenorhabditis elegans

Alignment Length:	246	Identity:	155/246 - (63%)
Similarity:	190/246 - (77%)	Gaps:	0/246 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 MSRKFCVGGNWKMNGDQKSIAEIAKTLSSAALDPNTEVVIGCPAIYLMYARNLLPCELGLAGQNA 166
            |:|||.||||||||||..|:..|...|:::|.:.:.:||:..||.||.||::.|...:.:|.||.
Worm     1 MTRKFFVGGNWKMNGDYASVDGIVTFLNASADNSSVDVVVAPPAPYLAYAKSKLKAGVLVAAQNC 65

  Fly   167 YKVAKGAFTGEISPAMLKDIGADWVILGHSERRAIFGESDALIAEKAEHALAEGLKVIACIGETL 231
            |||.||||||||||||:||:|.:||||||||||.:|||||||||||..|||..|:||:.||||.|
Worm    66 YKVPKGAFTGEISPAMIKDLGLEWVILGHSERRHVFGESDALIAEKTVHALEAGIKVVFCIGEKL 130

  Fly   232 EEREAGKTNEVVARQMCAYAQKIKDWKNVVVAYEPVWAIGTGQTATPDQAQEVHAFLRQWLSDNI 296
            ||||||.|.:|..||:.|...|...|:|:|:|||||||||||:||:.:||||||.::|.:|.:.:
Worm   131 EEREAGHTKDVNFRQLQAIVDKGVSWENIVIAYEPVWAIGTGKTASGEQAQEVHEWIRAFLKEKV 195

  Fly   297 SKEVSASLRIQYGGSVTAANAKELAKKPDIDGFLVGGASLKPEFVDIINAR 347
            |..|:.:.||.|||||||.||.||.|||||||||||||||||:||.|||||
Worm   196 SPAVADATRIIYGGSVTADNAAELGKKPDIDGFLVGGASLKPDFVKIINAR 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tpi	NP_788764.1	PTZ00333	102..346	CDD:240365	152/243 (63%)
tpi-1	NP_001366651.1	PTZ00333	1..245	CDD:240365	152/243 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158957
Domainoid	1	1.000	295	1.000	Domainoid score	I800
eggNOG	1	0.900	-	-		E1_COG0149
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H128432
Inparanoid	1	1.050	308	1.000	Inparanoid score	I1572
Isobase	1	0.950	-	0	Normalized mean entropy	S344
OMA	1	1.010	-	-		QHG62471
OrthoDB	1	1.010	-	-		D1272577at2759
OrthoFinder	1	1.000	-	-		FOG0002444
OrthoInspector	1	1.000	-	-		oto19578
orthoMCL	1	0.900	-	-		OOG6_100657
Panther	1	1.100	-	-	LDO	PTHR21139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1539
SonicParanoid	1	1.000	-	-		X1627
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790