DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and KRT37

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_003761.3	Gene:	KRT37 / 8688	HGNCID:	6455	Length:	449	Species:	Homo sapiens

Alignment Length:	246	Identity:	56/246 - (22%)
Similarity:	82/246 - (33%)	Gaps:	60/246 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 MAGPYPVYSCPNVDDDCVTFEPPAGPATQFSS-----CQKNVLGEGNANRLCQKHSSPRLRQMHI 372
            |...|...|||.   .| |..|  |....|.|     ||.  :.|.||..:|...:.....::.:
Human     1 MTSFYSTSSCPL---GC-TMAP--GARNVFVSPIDVGCQP--VAEANAASMCLLANVAHANRVRV 57

  Fly   373 SNTRSCVLCGEDVSWLPKVA--ACPCCGYKPVP--------EFKERPYDEQATAQQILLDHLENP 427
            .:|.    .|.....||..:  |||..|...:|        ..|......:....:.|.|.|.|.
Human    58 GSTP----LGRPSLCLPPTSHTACPLPGTCHIPGNIGICGAYGKNTLNGHEKETMKFLNDRLANY 118

  Fly   428 VENLSFDMGSVEGCSANEEHGVPEPT----SEAFEAIV-KDYQLLRRSIRESNTKATQSATKNPT 487
            :|.:.         ...:|:...|.|    |:..|:.| .|||...|:|.|...|...|..:|
Human   119 LEKVR---------QLEQENAELETTLLERSKCHESTVCPDYQSYFRTIEELQQKILCSKAEN-- 172

  Fly   488 AQEGSAQPQDLAKVFTEL------RDLFNVKAADENQKIQDICAEACALAK 532
                       |::..::      .|.|.:|...|....|.:.|:.|...|
Human   173 -----------ARLIVQIDNAKLAADDFRIKLESERSLHQLVEADKCGTQK 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	39/183 (21%)
KRT37	NP_003761.3	Head	1..104		27/114 (24%)
		Filament	104..414	CDD:278467	29/131 (22%)
		Coil 1A	105..139		8/42 (19%)
		Linker 1	140..150		3/9 (33%)
		Coil 1B	151..251		17/75 (23%)
		Linker 12	252..267
		Coil 2	268..411
		POX	319..>370	CDD:295429
		Tail	416..449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900