DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and Krt28

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_081850.1	Gene:	Krt28 / 70843	MGIID:	1918093	Length:	462	Species:	Mus musculus

Alignment Length:	451	Identity:	86/451 - (19%)
Similarity:	153/451 - (33%)	Gaps:	143/451 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 GRLAG----GQERGCFP-NMNVDLQDLSFMSTSSIDPCVGFMPSDTEVAQDSPPCSEDRAQDSFQ 302
            |.::|    |.|.|... |..|.:|:|:....|.:|.......:::|:.:......|
Mouse    65 GNVSGVCFIGSEGGLLSGNEKVTMQNLNNRLASYLDNVKALEEANSELERKIKTWHE-------- 121

  Fly   303 CQDSPPRLIDMAGPYPVYSCPNVDDDC----VTFEPPAGPATQFSSCQKNVLGEGNANRLCQKHS 363
                         .|...||..:|.|.    :|.|.........::...|::.:.:..||..  .
Mouse   122 -------------KYGPGSCRGLDRDYSKYHLTIEDLKSKIISSTAANANIILQIDNARLAA--D 171

  Fly   364 SPRLR-----------QMHISNTR----SCVLC-----------GEDVSWLP-------KVAACP 395
            ..||:           :..|:..|    ...||           .|::::|.       ||..|.
Mouse   172 DFRLKYENELTLHQNVEADINGLRRVLDELTLCRTDQELQYESLSEEMTYLKKNHEEEMKVLQCA 236

  Fly   396 CCG------------------------YKPVPEFKERP-----YDEQATAQQILLDHLENPVENL 431
            ..|                        |:.:.|...|.     .::.||.||           .:
Mouse   237 AGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSATLQQ-----------QI 290

  Fly   432 SFDMGSVEGCSANEEHGVPEPTSEAFEAIVKDYQLLRRSIRESNTKATQSATKNPTAQ---EGSA 493
            |.|:|:  ..||..|....:.:.:..|..::.....:.|: |.:...|:....:..||   :.||
Mouse   291 SNDLGA--ATSARTELTELKRSLQTLEIELQSLSATKHSL-ECSLAETEGNYCSQLAQIQAQISA 352

  Fly   494 QPQDLAKVFTEL-------RDLFNVKAADENQKIQDIC------AEACALAKSHKK--SKNRPAS 543
            ..:.|.:|.||.       ..|.::||..| ::|:..|      ..:|:::|..:.  |.|.|..
Mouse   353 LEEQLHQVRTETEGQKLEHEQLLDIKAHLE-KEIETYCRLIDGDENSCSVSKGFESGTSGNSPKD 416

  Fly   544 PERTKAGKTDPVEDACETPRKMKKRRPKVKRPYKSRYYSMYRPTERPKANVAIPDADKKVP 604
            ..:|...|| .||:.        .:|.||   ..||.:|:    |...:.::...|:::||
Mouse   417 VSKTTLVKT-VVEEI--------DQRGKV---LSSRIHSI----EEKMSKMSNGKAEQRVP 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	12/55 (22%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	61/303 (20%)
Krt28	NP_081850.1	Head. /evidence=ECO:0000255	1..83		5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Filament	83..397	CDD:365827	61/351 (17%)
		Coil 1A. /evidence=ECO:0000255	84..119		6/34 (18%)
		Linker 1. /evidence=ECO:0000255	120..141		6/41 (15%)
		Coil 1B. /evidence=ECO:0000255	142..233		13/92 (14%)
		Linker 12. /evidence=ECO:0000255	234..256		2/21 (10%)
		Coil 2. /evidence=ECO:0000255	257..395		31/152 (20%)
		Tail. /evidence=ECO:0000255	396..462		20/82 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900