DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and Krt25

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_598491.1	Gene:	Krt25 / 70810	MGIID:	1918060	Length:	446	Species:	Mus musculus

Alignment Length:	178	Identity:	31/178 - (17%)
Similarity:	52/178 - (29%)	Gaps:	75/178 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 CLGSSSINV--NCLP-------LN----------------PDKTFQMEAECLQRQLAEGINISVV 177
            |....::||  |..|       ||                .:..||.::..||:|:.|.:. :..
Mouse   226 CAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSASLQQQITEDVG-ATT 289

  Fly   178 YLRKEI------------------------------ARGCYFPPAAVVSRMINDFDEIVHDANVE 212
            ..|.|:                              ..|.|....|.:...|:..:|.:|....|
Mouse   290 SARNELTEMKRTLQTLEIELQSLLATKHSLECSLTETEGNYCTQLAQIQAQISALEEQLHQVRTE 354

  Fly   213 LTCKGCTVG-------IMNIRFAMQMRCQTLKEDAVDGRLAGGQERGC 253
                  |.|       ::|::..::...:|.      ..|.||.|..|
Mouse   355 ------TEGQKLEYEQLLNVKAHLEKEIETY------CLLIGGDEGAC 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	31/178 (17%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622
Krt25	NP_598491.1	Head. /evidence=ECO:0000255	1..74
		Filament	74..387	CDD:278467	29/173 (17%)
		Coil 1A. /evidence=ECO:0000255	75..110
		Linker 1. /evidence=ECO:0000255	111..132
		Coil 1B. /evidence=ECO:0000255	133..224
		Linker 12. /evidence=ECO:0000255	225..247		5/20 (25%)
		Coil 2. /evidence=ECO:0000255	248..386		23/150 (15%)
		YlqD	334..>377	CDD:287979	8/48 (17%)
		Tail. /evidence=ECO:0000255	387..446		2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900