DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and Krt27

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_001008824.1	Gene:	Krt27 / 450229	RGDID:	1359115	Length:	449	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	91/473 - (19%)
Similarity:	155/473 - (32%)	Gaps:	143/473 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 NVELTCKGCTVGIMNI----RFAMQMRCQTLKEDAVDGRLAGGQERGCFP---------NMNVDL 261
            :|.|:..|..:|..|.    .......|.........|...||...|.|.         |..|.:
  Rat    14 SVRLSSPGAALGAGNTCGVPGIGSGFSCAFGGSSLAGGLGMGGASCGAFTVNEHGLLSGNEKVTM 78

  Fly   262 QDLSFMSTSSIDPCVGFMPSDTEVAQDSPPCSEDRAQDSFQCQDSPPRLIDMAGPYPVYSCPNVD 326
            |:|:....|.::        :.:..:::....|.:.:|.:          :..||   .||..:|
  Rat    79 QNLNDRLASYLE--------NVQALEEANADLEQKIKDWY----------EKFGP---GSCRGLD 122

  Fly   327 DDCVTFEPPAGP-ATQFSSCQKNVLGEGNANRLCQKHSSP------RLR-----QMH------IS 373
            .|...:.|.... .||..|....     |||.:.|..::.      |::     .:|      |:
  Rat   123 HDYSRYFPIIDDLRTQIISATAQ-----NANIVLQNDNARLTADDFRMKYENELALHQSVDADIN 182

  Fly   374 NTR----SCVLC-----------GEDVSWLPK-----VAACPCCG-------------------- 398
            ..|    ...||           .|::::|.|     :.|..|..
  Rat   183 GLRRVLDELTLCRTDLEVQLETLSEELAYLKKNHEEEMQALQCAAGGNVNVEMNAAPGVDLTVLL 247

  Fly   399 ------YKPVPEFKERP----YDEQATAQQILLDHLENPVENLSFDMGSVEGCSANEEHGVPEPT 453
                  |:.:.|...|.    :.|::.:.|          :.:|.|.|:.  .||..|....:.|
  Rat   248 NNMRAEYEALAEQNRRDAEAWFQEKSASLQ----------QQISDDAGAT--TSARNELTEMKRT 300

  Fly   454 SEAFEAIVKDYQLLRRSIRESNTKATQSATKNPTAQ---EGSAQPQDLAKVFT-------ELRDL 508
            .:..|..::....::.|:..|.|: |:.......||   :.||..:.|.:|.|       |...|
  Rat   301 LQTLEIELQSLLAMKHSLECSLTE-TEGNYCTQLAQIQAQISALEEQLHQVRTETEGQKLEYEQL 364

  Fly   509 FNVKAADENQKIQDICAEACALAKSHKKSKNRPASPERTK-AGKTDPVEDACE--TPR------- 563
            .||||..| ::|:..|........|..|||.:.....:|| :.||..|:...|  .||
  Rat   365 LNVKAHLE-KEIETYCLLIGGDEGSCVKSKGQGGPGNQTKDSPKTAIVKTVVEELDPRGKVLSSR 428

  Fly   564 --KMKKRRPKVKRPYKSR 579
              .::::..||....:.|
  Rat   429 VHTLEEKSTKVNNKNEQR 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	16/96 (17%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	58/287 (20%)
Krt27	NP_001008824.1	Head. /evidence=ECO:0000255	1..73		11/58 (19%)
		Filament	73..386	CDD:278467	65/352 (18%)
		Coil 1A. /evidence=ECO:0000255	74..109		5/42 (12%)
		Linker 1. /evidence=ECO:0000255	110..131		6/33 (18%)
		Coil 1B. /evidence=ECO:0000255	132..223		16/95 (17%)
		Linker 12. /evidence=ECO:0000255	224..246		1/21 (5%)
		Coil 2. /evidence=ECO:0000255	247..385		33/151 (22%)
		YlqD	333..>376	CDD:287979	14/43 (33%)
		Tail. /evidence=ECO:0000255	386..449		15/61 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..449		3/22 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900