DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppi1 and KRT34

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	XP_011523095.1	Gene:	KRT34 / 3885	HGNCID:	6452	Length:	412	Species:	Homo sapiens

Alignment Length:	415	Identity:	68/415 - (16%)
Similarity:	140/415 - (33%)	Gaps:	109/415 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 LRQMHISNTRSCVLCGEDVSWLPKVAACPCCGYKP-VPE----------------------FKER 408
            |..:.:|.|.|...|      ||.:.....|..:| ||.                      |.|.
Human    10 LAPIFVSCTMSYSCC------LPSLGCRTSCSSRPCVPPSCHGYTLPGACNIPANVSNCNWFCEG 68

  Fly   409 PYD-EQATAQQILLDHLENPVENLSFDMGSVEGCSANEEHGVPEPTSEAFEAIVKDYQLLRRSIR 472
            .:: .:....|.|.|.|.:.:|.:.    .:|..:|..|..:.|.:.:....:...||...::|.
Human    69 SFNGSEKETMQFLNDRLASYLEKVR----QLERDNAELEKLIQERSQQQEPLLCPSYQSYFKTIE 129

  Fly   473 E-------------------SNTKATQSATKNPTAQEGSAQ---PQDLAKVFTELRDLFNVKAAD 515
            |                   .|.|......::....|.|.:   ..|:..:...|.:|...|:..
Human   130 ELQQKILCAKAENARLVVNIDNAKLASDDFRSKYQTEQSLRLLVESDINSIRRILDELTLCKSDL 194

  Fly   516 ENQKIQDICAEACALAKSHKKSKNRPASPERTKAG-------KTDPVED---ACETPRKMKKRRP 570
            |:| ::.:..|...|.|:|::..|    ..|::.|       .|.|..|   .....|...:...
Human   195 ESQ-VESLREELICLKKNHEEEVN----TLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEALV 254

  Fly   571 KVKRPYKSRYYSMYRPTERPKANVAIPDADKKVPSHMGWLWTAHPLANKPGWRPGAIRRSIRGL- 634
            ::.|....::::    |:..:.|..:..:.:::.|....:.              .:||::..|
Human   255 EINRREVEQWFA----TQTEELNKQVVSSSEQLQSCQAEII--------------ELRRTVNALE 301

  Fly   635 ----MSYFLKDFPVDNVPVSKYMSYYKHKMSPMSPPGEKAEDLVQVPTLHIEKKNDVYTI----- 690
                ..:.|:| .::|. :::..::|..::|.:.......|..:......:|::|..|.:
Human   302 IELQAQHNLRD-SLENT-LTESEAHYSSQLSQVQSLITNVESQLAEIRCDLERQNQEYQVLLDVR 364

  Fly   691 --------TLRPLKDAKTLARSANP 707
                    |.|.|.:::......||
Human   365 ARLECEINTYRSLLESEDCKLPCNP 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	67/411 (16%)
KRT34	XP_011523095.1	Filament	73..384	CDD:278467	53/339 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900