DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and KRT32

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_002269.3	Gene:	KRT32 / 3882	HGNCID:	6449	Length:	448	Species:	Homo sapiens

Alignment Length:	472	Identity:	76/472 - (16%)
Similarity:	141/472 - (29%)	Gaps:	198/472 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SSCPVRNREEVYQPRCPAPGQKGKPNRDYMRCFAAKLIVQKLNMPGRDFECQDKLQIKANVCR-- 133
            |||.|.|..:.....||.|                                       |:||.
Human     3 SSCCVTNNLQASLKSCPRP---------------------------------------ASVCSSG 28

  Fly   134 -GCK--ICLGSSSINVNCLPLNPDKTFQMEAECLQRQLAEGINISVVYLRKEIARGCYFPPAAVV 195
             .|:  :|||.....:.|||          :.||...                     |.||:.:
Human    29 VNCRPELCLGYVCQPMACLP----------SVCLPTT---------------------FRPASCL 62

  Fly   196 SRMINDFDEIVHDANVELTCKGCTVGIMNIRFAMQMRCQTLKEDAVDGRLAGGQ--ERGCFPNMN 258
            |:..                             :...||.  ...:.|.:..|.  ..|.| |.|
Human    63 SKTY-----------------------------LSSSCQA--ASGISGSMGPGSWYSEGAF-NGN 95

  Fly   259 VDLQDLSFMSTSSIDPCVGFMPSDTEVAQDSPPCSEDRAQDSFQCQDSPPRLIDMAGPYPVYSCP 323
             :.:.:.|::    |....::....::.|::... |.|.|::     |..:::.|.        |
Human    96 -EKETMQFLN----DRLASYLTRVRQLEQENAEL-ESRIQEA-----SHSQVLTMT--------P 141

  Fly   324 NVDDDCVTFEPPAGPATQFSSCQKNVLGEGNANRLCQKHSSPRLRQMHISNTRSCVLCGEDVSWL 388
            :......|.|          ..|:.:        ||.|..:.|: .::|.|.
Human   142 DYQSHFRTIE----------ELQQKI--------LCTKAENARM-VVNIDNA------------- 174

  Fly   389 PKVAACPCCGYKPVPEFKERPYDEQATAQQILLDHLENPVENLSFDMGSVEGCSANEEHGVPEPT 453
             |:||         .:|:.: |:.:...:|:    :|..:..|...:..:..|.|:.|..|
Human   175 -KLAA---------DDFRAK-YEAELAMRQL----VEADINGLRRILDDLTLCKADLEAQV---- 220

  Fly   454 SEAFEAIVKDYQLLRRSIRESNTKATQSATKNPTAQEGSAQPQDLAKVFTELR------------ 506
                |::.::...|:::..|...............:..:|.|.||.:|..|:|
Human   221 ----ESLKEELMCLKKNHEEEVGSLRCQLGDRLNIEVDAAPPVDLTRVLEEMRCQYEAMVEANRR 281

  Fly   507 ---DLFNVKAADENQKI 520
               :.||::..:.||::
Human   282 DVEEWFNMQMEELNQQV 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	27/192 (14%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	28/165 (17%)
KRT32	NP_002269.3	Head	1..96		32/195 (16%)
		Filament	95..406	CDD:278467	45/278 (16%)
		Coil 1A	97..131		6/38 (16%)
		Uso1_p115_C	112..230	CDD:282695	29/186 (16%)
		Linker 1	132..142		2/17 (12%)
		Coil 1B	143..243		24/154 (16%)
		Linker 12	244..259		1/14 (7%)
		Coil 2	260..403		9/39 (23%)
		Prefoldin	275..>355	CDD:298833	4/24 (17%)
		Tail	404..448
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900