DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppi1 and KRT19

DIOPT Version :9

Sequence 1:	NP_733345.2	Gene:	Ppi1 / 43581	FlyBaseID:	FBgn0051025	Length:	998	Species:	Drosophila melanogaster
Sequence 2:	NP_002267.2	Gene:	KRT19 / 3880	HGNCID:	6436	Length:	400	Species:	Homo sapiens

Alignment Length:	327	Identity:	60/327 - (18%)
Similarity:	107/327 - (32%)	Gaps:	117/327 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 AVDGRLAGGQERGCFPNMNVDLQDLSFMSTSSIDPCVGFMPSDTEVAQDSPPCSEDRAQDSFQCQ 304
            |.||.|||        |..:.:|:|:....|.:|.......::.|:        |.:.:|.:|.|
Human    71 ASDGLLAG--------NEKLTMQNLNDRLASYLDKVRALEAANGEL--------EVKIRDWYQKQ 119

  Fly   305 DSPPRLIDMAGPYPVYSCPNVDDDCVTFEPPAGPATQFS-------SCQKNVLGEGNAN-RLCQK 361
                      ||                    ||:..:|       ..:..:||....| |:.
Human   120 ----------GP--------------------GPSRDYSHYYTTIQDLRDKILGATIENSRIV-- 152

  Fly   362 HSSPRLRQMHISNTRSCVLCGEDVSWLPKVAACPCCGYKPVPEFKERPYDEQATAQQILLD--HL 424
                    :.|.|.|   |..:|                    |:.:...|||....:..|  .|
Human   153 --------LQIDNAR---LAADD--------------------FRTKFETEQALRMSVEADINGL 186

  Fly   425 ENPVENLSFDMGSVEGCSANEEHGVPEPTSEAFEAIVKDYQLLRRSIRESNTKATQSATKNPTAQ 489
            ...::.|:.....:|               ...|.:.::...|:::..|..:..........:.:
Human   187 RRVLDELTLARTDLE---------------MQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVE 236

  Fly   490 EGSAQPQDLAKVFTELRDLFNVKAADENQKIQDICAEACALAKSHKKSKNRPASPERTKAGKTDP 554
            ..||...||||:.:::|..:.| .|::|:|      :|.|...|..:..||..      ||.|:.
Human   237 VDSAPGTDLAKILSDMRSQYEV-MAEQNRK------DAEAWFTSRTEELNREV------AGHTEQ 288

  Fly   555 VE 556
            ::
Human   289 LQ 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppi1	NP_733345.2	DUF4788	108..>294	CDD:292651	12/53 (23%)
Ppi1	NP_733345.2	DUF4776	371..848	CDD:292622	35/188 (19%)
KRT19	NP_002267.2	Head	1..79		6/15 (40%)
		Filament	79..390	CDD:278467	54/311 (17%)
		Coil 1A	80..115		6/42 (14%)
		Linker 1	116..133		7/46 (15%)
		Coil 1B	134..225		20/138 (14%)
		Linker 12	226..248		5/21 (24%)
		Necessary for interaction with PNN. /evidence=ECO:0000269\|PubMed:10809736	244..390		17/60 (28%)
		Coil 2	249..387		13/55 (24%)
		Rod-like helical tail	388..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900